Sort   by:  
 Page size 
TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-20015 | biostudies-arrayexpress
ProteomicsGSK-3 Interactomes from APMS and BioID
Interactomes of GSK-3 Isoforms compared by APMS (in HEK293) and BioID (in HEK293 and HeLa cells).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-15 | MSV000090908 | MassIVE
TranscriptomicsLithium promotes longevity via GSK-3 and NRF-2 and is additive to other anti-aging interventions
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophi...
ORGANISM(S): Drosophila melanogaster 
2016-04-07 | E-MTAB-3809 | biostudies-arrayexpress
TranscriptomicsGene expression in astrocytes upon sustained GSK-3 inhibition by small molecule
In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with e...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-25770 | biostudies-arrayexpress
TranscriptomicsAnalysis of Gsk-3-Deficient Embryonic Stem Cells Reveals Large-Scale Alterations in Gene Expression
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in significant changes in gene expression. In contrast,...
ORGANISM(S): Mus musculus 
2011-09-14 | E-GEOD-27395 | biostudies-arrayexpress
TranscriptomicsGSK-3A and GSK-3B knockdown in AML cell lines
Gene expression data from AML cell lines, MOLM-14, U937, THP-1 and HL-60, that were infected with a scrambled control hairpin (shControl), two shRNAs directed against GSK-3B (shGSK3B_1 and shGSK3B_2), or two shRNAs directed against GSK-3A (shGSK3A_5 and shGSK3A_6). Acute myeloid leukemia (AML) is th...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-35200 | biostudies-arrayexpress
TranscriptomicsGSK-3 inhibitor treatment effect on MLL leukemia cell
Human leukemia cell line RS4.11 was treated with GSK-3 inhibitor SB216763 for 20 hours. Gene expression profiling was performed to analyze genes affected by GSK-3 inhibition. Human leukemia cell line RS4.11 was grown in vitro and treated with 10 uM GSK-3 inhibitor SB216763 or solvent DMSO for 20 h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-19736 | biostudies-arrayexpress
GenomicsTranscriptomic changes induced by Gsk-3-deletion in cerebellar progenitors
Transcriptomic changes induced by Gsk-3-deletion in cerebellar progenitors
PRJNA558975 | ENA
GenomicsSensitivity of splicing factor mutant hematopoietic cells to GSK-3 inhibition
Sensitivity of splicing factor mutant hematopoietic cells to GSK-3 inhibition
PRJNA986530 | ENA
TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | GSE20015 | GEO
Sort   by:  
 Page size