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ProteomicsInhibition of histone methyltransferase EZH2 in Schistosoma mansoni by GSK343 decreases the expression of genes implicated in DNA replication and ncRNA metabolism
Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus Schistosoma. The current strategy for the control of the disease involves treatment with Praziquantel, the only available drug. The development of new drugs is therefore a top priority. Drugs that inhibit histon...
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2018-11-23 | PXD010342 | Pride
Proteomics Schistosoma mansoni Ezh2 Gsk343 Rna-seq 
TranscriptomicsTreatment of CML CD34+ cells with EZH2 inhibitor GSK343
Transcriptional profiling by array of CML CD34+ cells to understand the response of chronic myeloid leukaemia stem cells to an EZH2 inhibitor, GSK343.
ORGANISM(S): Homo sapiens 
2016-11-01 | E-MTAB-2893 | biostudies-arrayexpress
TranscriptomicsTreatment of non-CML CD34+ cells with EZH2 inhibitor GSK343
Transcriptional profiling of non-CML CD34+ cells to understand the response of non-CML stem cells to an EZH2 inhibitor, GSK343.
ORGANISM(S): Homo sapiens 
2016-11-01 | E-MTAB-3552 | biostudies-arrayexpress
GenomicsStudy the differential gene expression in A375 cells treated with DMSO or XL413 or GSK343 or GSK343 and XL413 combination
Study the differential gene expression in A375 cells treated with DMSO or XL413 or GSK343 or GSK343 and XL413 combination
PRJNA773103 | ENA
GenomicsGenes regulated by GSK343 in HepG2 and A549 cells
Genes regulated by GSK343 in HepG2 and A549 cells
PRJNA530526 | ENA
GenomicsPolyA RNA-seq from retinoic acid-differentiated iPSCs treated with GSK343, 5-aza, or Combo (GSK343 & 5-aza)
PolyA RNA-seq from retinoic acid-differentiated iPSCs treated with GSK343, 5-aza, or Combo (GSK343 & 5-aza)
PRJNA854948 | ENA
GenomicsGenes regulated by GSK343 in HepG2 and PLC5 hepatocellular carcinoma cells
Genes regulated by GSK343 in HepG2 and PLC5 hepatocellular carcinoma cells
PRJNA530523 | ENA
TranscriptomicsStudy the differential gene expression in A375 cells treated with DMSO or XL413 or GSK343 or GSK343 and XL413 combination
The study evaluated the differential gene expression in A375 cells treated with DMSO when compared to XL413 or GSK343 or GSK343 and XL413 combination using RNA-seq
ORGANISM(S): Homo sapiens 
2022-08-10 | GSE186276 | GEO
UnknownGSK343 induces programmed cell death through the inhibition of EZH2 and FBP1 in osteosarcoma cells.
Not available
S-EPMC7012145 | biostudies-literature
UnknownThe EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells.
Not available
S-EPMC5716734 | biostudies-literature
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