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ProteomicsRas-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
In this study, we deciphered cellular mechanisms underlying AXIN1 loss by MEK1/2 inhibition in colorectal cancer (CRC). We observed that both MEK1/2 and GSK3B inhibitors strongly reduce AXIN1 levels across multiple CRC models. Inhibition of MEK1/2, but not GSK3B, causes a reduction of AXIN1 transcri...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD067308 | Pride
Gsk3b inhibition Mek inhibition Hct116 Immunoprecipitation Lc-ms/ms Colorectal cancer 
GenomicsBeta-catenin deletion and GSK3b inhibition in B-ALL cells
Beta-catenin deletion and GSK3b inhibition in B-ALL cells
PRJNA1027763 | ENA
UnknownInhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Not available
S-EPMC4639830 | biostudies-literature
TranscriptomicsGene expression in astrocytes upon sustained GSK-3 inhibition by small molecule
In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with e...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-25770 | biostudies-arrayexpress
GenomicsA Novel role for GSK3B as a modulator of Drosha Microprocessor activity and microRNA biogenesis
Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here we identify the kinase GSK3B as an important modulator of global miR biogenesis at microprocessor level. Repression of GSK3B activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed p...
ORGANISM(S): Homo sapiens 
2016-05-20 | GSE81141 | GEO
UnknownGSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis.
Not available
S-EPMC4077702 | biostudies-literature
UnknownGSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1.
Not available
S-EPMC12618078 | biostudies-literature
ProteomicseIF4E2 regulates GSK3b kinase activity
we found eIF4E2 regulates GSK3b kinase activity. And we performed the quantitative iTRAQ-based phosphoproteomic to identify phophosites regulated by eIF4E2-GSK3b pathway
ORGANISM(S): Homo Sapiens 
2021-02-17 | PXD024226 |
TranscriptomicsBeta-catenin deletion and GSK3b inhibition in B-ALL cells
In most cell types, nuclear β-catenin functions as prominent oncogenic driver and pairs with TCF7-family factors for transcriptional activation of MYC. Surprisingly, B-lymphoid malignancies not only lacked expression and activating lesions of β-catenin but critically depended on GSK3b for effective ...
ORGANISM(S): Mus musculus 
2025-08-08 | GSE245287 | GEO
UnknownGLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway.
Not available
S-EPMC4621609 | biostudies-literature
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