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TranscriptomicsGene expression analysis of B cell lymphomas from representative IµHABcl6, IµHABcl6 Ung-/- Msh2-/-, and IµHABcl6 Msh2-/- mouse models.
Somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes are genomic modification events that occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation induced cytidine deaminase (AID). Resulting uracil-guani...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-48304 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation maps in chronic lymphocytic leukemia cells determined by next-generation sequencing
We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from CLL patient and normal control samples using reduced representation bisulfite sequencing (RRBS). The methylation status of 1.8-2.3 million CpGs in the CLL genome was determined; about 45% of these CpGs were located in more tha...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-32698 | biostudies-arrayexpress
ProteomicsIL7R mutational activation can initiate Ph-like and PAX5 P80R precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological level...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD017147 | Pride
Acute lymphoblastic leukemia B cells 
TranscriptomicsGene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Identification of the molecular changes that promote viability and metastatic behaviour of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate canc...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17482 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells, CD27 memory B-cells, polyclonal plasmablastic cells and human myeloma cell lines
Gene expression profiling of CD138 purified bone marrow plasma cells of healthy donors, CD27 memory B-cells, cultured ployclonal plasmablastic cells and cultured human myeloma cell lines. Samples from healthy donors have been re-used from ArrayExpress experiment E-MEXP-2360. Some of the myeloma cell...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5212 | biostudies-arrayexpress
UnknownA proposal of Bursaphelenchus uncispicularis Zhuo, Li, Li, Yu & Liao, 2007 as a junior synonyms of B. yongensis Gu, Braasch, Burgermeister, Brandstetter & Zhang, 2006.
Not available
S-EPMC8015284 | biostudies-literature
TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of ABC from Bm12-induced lupus model
Age-associated B cells (ABCs) accumulate in systemic autoimmunity, and contributes to pathogenesis. ABCs are characterized by high expression of CD11c and T-bet. As a transcription factor, T-bet cannot be labeled in live cells with antibodies, so we constructed a reporter mouse strain in which fluor...
ORGANISM(S): Mus musculus 
2023-02-16 | E-MTAB-12568 | biostudies-arrayexpress
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
ProteomicsCyclin A triggers Mitosis either via Greatwall or Cyclin B
Two mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1. Cells lacking Cyclin B...
ORGANISM(S): Homo sapiens (Human) 
2020-05-21 | PXD012100 | Pride
Human Phosphoproteomics Cyclin Cell cycle Mitosis 
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