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TranscriptomicsTranscription profiling of mouse beta cells lacking NeuroD
The goal: Investigate NeuroD function in the mature beta cells. The model: Cross RIP-Cre to NeuroD flox/flox mouse to delete neuroD when insulin gene is activated; The methods: Islets are purified and RNA is extracted to see how the profile of gene expression is altered after neuroD is deleted...
ORGANISM(S): Mus musculus 
2010-03-03 | E-MTAB-152 | biostudies-arrayexpress
TranscriptomicsEffect of human breast tumor supernatant on normal CD4+ T cells (Confirmation Set SN)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36766 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD4+ T cells infiltrating human breast cancer (Discovery Set)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36765 | biostudies-arrayexpress
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
TranscriptomicsCD4+ TIL in human breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36769 | biostudies-arrayexpress
TranscriptomicsSlr0643, a S2P Homolog, Is Essential for Acid Acclimation in Cyanobacterium Synechocystis sp. PCC 6803
Every cyanobacterial species contains gene encoding site-2-protease (S2P) homolog. The studied prokaryotic S2P homologs play essential roles in regulating stress response through intramembrane proteolysis of membrane-bound anti-sigma factors. Here, gene of Slr0643, one of four S2P homologs in Synech...
ORGANISM(S): Synechocystis sp. PCC 6803 
2012-09-18 | E-GEOD-37747 | biostudies-arrayexpress
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
TranscriptomicsGene changes of CD4+ T cells infiltrating human breast cancer in the absence of tumor environment (Confirmation Set 24h)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36767 | biostudies-arrayexpress
TranscriptomicsEffect of human breast tumor supernatant on normal CD4+ T cells (Preliminary Experiment)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36768 | biostudies-arrayexpress
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [Tat]
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-33705 | biostudies-arrayexpress
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