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ProteomicsSelenite metabolism and reduction in Ganoderma lucidum
G. lucidum could reduce selenite to element Se and further aggregated into selenium nanoparticles (SeNPs), simultaneously accompanying by the production of pungent odorous volatile selenium metabolites. iTRAQ-based quantitative proteomic analysis revealed the abundance of proteins involved in sele...
ORGANISM(S): Ganoderma Lucidum G.260125-1 
2022-08-03 | PXD035786 |
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
PXD037648 |
ProteomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity
The programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingo...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD075012 |
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