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TranscriptomicsComparative genomic hybridization of 30 ovarian cancer cell lines reveals amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer
DNA from 30 cultured ovarian cancer cell lines was extracted with Promega kits and hybridize to arrays. Arrays comprised of 1860 BACs selected to include genes known to be involved in cancer pathogenesis and 400 BACs selected to tile across 13 Mbp at 3q26, 15 Mbp at 8q24, and 30 Mbp at 20q centered ...
ORGANISM(S): Homo sapiens 
2007-06-04 | E-TABM-246 | biostudies-arrayexpress
GenomicsMMP-seq tumor samples (FASTQ) - samples
MMP-seq tumor samples (FASTQ)
EGAD00001001108 | EGA
GenomicsMMP-seq cell lines (FASTQ) - samples
MMP-seq cell lines (FASTQ)
EGAD00001001107 | EGA
GenomicsMMP-seq tumor samples, UDG treated (FASTQ) - samples
MMP-seq tumor samples, UDG treated (FASTQ)
EGAD00001001104 | EGA
GenomicsHigh-throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples By Multiplexed PCR and Next Generation Sequencing
PURPOSE: Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false positive rates. Here, we describe a novel methodology, M...
EGAS00001000674 | EGA
GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
GenomicsThe mutation spectrum revealed by paired genome sequences from a lung cancer patient

Whole genome sequencing was applied to tumor and adjacent normal lung tissue in an individual non-small-cell lung cancer patient. We present an analysis of somatic changes identified throughout the tumor genome, including single-nucleotide variants, copy number variants, and large-scale chrom...

phs000299.v1.p1 | EGA
GenomicsGenentech whole genome and transcriptome sequencing of four hepatocellular carcinoma patients

Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). In this study we sequenced the whole genome (~80X) and transcriptome of tumor and non-tumor samples from four HCC patients and identified over two hundred HBV integration sites. We found significant clona...

phs000384.v1.p1 | EGA
GenomicsColon_Illumina_2.5M_Controls - samples
Colon matched tumour samples
EGAD00010000274 | EGA
GenomicsColon_Illumina_2.5M_Cases - samples
Colon tumour samples
EGAD00010000272 | EGA
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