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ProteomicsAn integrated strategy reveals complex glycosylation of erythropoi-etin using top-down and bottom-up mass spectrometry
The characterization of therapeutic glycoproteins is challenging due to the structural micro- and macro-heterogeneity of the protein glycosylation. This study presents an in-depth strategy for glycosylation analysis using first-generation erythropoietin (epoetin beta), including a developed top-down...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-14 | PXD024835 | Pride
Erythropoietin Bottom-up Top-down Mass spectrometry Glycosylation Python scripts 
ProteomicsNogo-B co-IP-MS experiment in mouse liver and pancreas
Co-immunoprecipitation with either rabbit normal IgG or anti-Nogo-B antibody followed by mass spectrometry (co-IP-MS) in the liver and pancreas of wild-type C57BL/6J mice.
ORGANISM(S): Mus musculus (Mouse) 
2024-07-27 | PXD046104 | Pride
Mouse liver and pancreas 
ProteomicsProtective mechanisms of heparin against AGEs-induced endothelial injury
Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug. This study investigated whether heparin could ameliorate AGEs-induced endothelial injury. Remarkably, heparin effectively ...
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD056219 |
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