Guanine - OmicsDI

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Instrument Platform

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UNIPROT ID/AC

P18825 (2)
P18089 (2)
P08913 (2)
P61970 (1)
P62826 (1)
P07278 (1)
P06245 (1)
P05986 (1)
P06244 (1)
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P01120 (1)
P04821 (1)
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Q15796 (1)
Q13485 (1)
P36897 (1)

CHEBI ID

CHEBI:15996 (4)
CHEBI:17552 (4)
CHEBI:62890 (3)
CHEBI:139151 (3)
CHEBI:85106 (3)
CHEBI:40356 (3)
CHEBI:67138 (3)
CHEBI:64076 (3)
CHEBI:64074 (3)
CHEBI:64077 (3)
CHEBI:64075 (3)
CHEBI:70731 (3)
CHEBI:13388 (3)
CHEBI:35098 (3)
CHEBI:34773 (3)
CHEBI:34606 (3)
CHEBI:74004 (3)
CHEBI:74007 (3)
CHEBI:134176 (3)
CHEBI:74853 (3)
CHEBI:71517 (3)
CHEBI:58838 (3)
CHEBI:58837 (3)
CHEBI:57677 (3)
CHEBI:60464 (3)
CHEBI:65078 (3)
CHEBI:48595 (3)
CHEBI:73682 (3)
CHEBI:27973 (3)
CHEBI:131350 (3)

Metabolite Name

Guanine (380)
Adenosine (272)
Hypoxanthine (270)
Adenine (248)
Creatine (235)
Cytosine (227)
Uracil (224)
Choline (215)
Guanosine (212)
Cytidine (209)
Inosine (208)
Creatinine (206)
Betaine (205)
Xanthine (188)
Riboflavin (185)
L-Tyrosine (180)
Thymine (178)
Oleamide (177)
L-Phenylalanine (176)
Spermidine (174)
L-Proline (173)
L-Histidine (172)
Uridine (167)
Indole (166)
Taurine (162)
L-Tryptophan (154)
Pyridoxine (149)
L-Valine (149)
Histamine (148)
L-Lysine (146)

First Public Date

2025 (61)
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2014 (34)
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2020 (26)
2019 (21)
2022 (20)
2018 (14)
2017 (11)
2016 (9)
2015 (5)
2012 (1)

Modelling Approach

Ordinary differential equation model (7)
Constraint-based model (4)

Lab affiliation

Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia (2)
chemistry biochemistry UCSD (2)
1Department of Chemistry, University of California, Riverside (1)
1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia (1)
Associate Professor, Department of Biochemistry & Molecular Biology, UTMB Mass Spectrometry Director, University of Texas Medical Branch – Galveston, Texas, USA (1)
Associate Professor, Neuroscience, The Scripps Research Institute Florida (1)
Bavarian Center for Biomolecular Mass Spectrometry Technische Universität München Gregor-Mendel-Straße 4 85354 Freising DEUTSCHLAND / GERMANY (1)
Bioanalytical Chemistry Section, Department of Biology/Chemistry, Osnabrück University, Germany (1)
Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Multidisciplinary Sciences, Goettingen Bioanalytics, Institute for Clinical Chemistry, Goettingen (1)
Biology Department Pennsylvania State University (1)
Brown University (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
CSIR-Institute of Genomics and Integrative Biology (1)
Cancer Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia (1)
Center for Plant Molecular Biology (ZMBP) University of Tübingen Tübingen, Germany (1)
Center for Thoracic Cancers, MGH Cancer Center Massachusetts General Hospital Harvard Medical School USA (1)
Centro Nacional de Biotecnología (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain (1)
Dartmouth College (1)
Debora Bonenfant, Novartis Institutes for Biomedical research, Basel, Switzerland (1)
Department Molekulare Systembiologie Helmholtz-Zentrum für Umweltforschung GmbH - UFZ Permoserstraße 15 | 04318 Leipzig (1)
Department of Biochemistry and Microbiology, University of Victoria, BC, Canada (1)
Department of Biomedicine, University of Bergen, Norway (1)
Department of Chemistry, University of California Riverside (1)
Department of Chemistry, University of California Riverside, Riverside, CA 92521-0403. (1)
Department of Chemistry, University of Manitoba, Canada (1)
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA (1)
Department of Medicine, University of California San Diego, La Jolla, California 92093 (1)
Department of Molecular Genetics, Weizmann Institute of Science; Rehovot, 7610001, Israel (1)
Department of Molecular Hematology, Sanquin Research, Amsterdam, the Netherlands (1)
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA (1)

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Transcription profiling by array (2786)
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Methylation profiling by array (52)
Comparative genomic hybridization by array (48)
Other (47)
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1998 (17)
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Guanine is an inhibitor of c-Jun terminal kinases

We have shown that JNKs are directly inhibited by guanine. We here quantify the proteome and phosphoproteome of mouse embryonic fibroblasts treated with guanine or vehicle.

ORGANISM(S): Mus musculus (Mouse)

2025-07-02 | PXD062305 | Pride

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication forks, DNA repair foci, ssRNA, and telomeres. The above functions require...

ORGANISM(S): Homo sapiens (Human) Escherichia coli

2023-11-13 | PXD043587 | Pride

Aicardi-goutieres syndrome Dna repair Rnase Sammhd1 Hiv

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

PRJNA683013 | ENA

G3BP1 Binds to Guanine Quadruplexes in mRNAs

PRJNA714642 | ENA

Guanine- and cytosine-rich genes are actively transcribed at the nuclear Lmnb1 compartment

PRJNA1031166 | ENA

Proteome-wide Identification of DNA Guanine Quadruplex-binding Proteins

DNA sequences of high guanine (G) content have the potential to fold into G quadruplex (G4) structures. DNA G4 is known to play important roles in various cellular processes including DNA replication, transcriptional regulation, and maintenance of genomic integrity. A more complete understanding abo...

ORGANISM(S): Homo sapiens (Human)

2021-09-29 | PXD026794 | Pride

G-quadruplex Silac Lc-ms/ms

Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions.

Not available

S-EPMC7503932 | biostudies-literature

Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.

Not available

S-EPMC9128948 | biostudies-literature

sepsis-secreted G6PD supports guanine generation and Histone H3K27 demethylation to Drive Inflammatory Macrophages

PRJNA964444 | ENA

Crosslinking MS of Elmo1,Dock5,Rac1 and RhoG complexes

Crosslink mass spectrometry of Elmo1,Dock5,Rac1 and RhoG complexes using BS3 crosslinker.

ORGANISM(S): Homo Sapiens (human)

2025-01-18 | PXD048862 | JPOST Repository

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