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TranscriptomicsBromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39909 | biostudies-arrayexpress
TranscriptomicsRoutine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples
This SuperSeries is composed of the following subset Series: GSE34577: Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples (training samples) GSE34714: Routine u...
ORGANISM(S): Homo sapiens 
2012-01-04 | E-GEOD-34823 | biostudies-arrayexpress
TranscriptomicsA specific CBP/p300-dependent gene expression program drives the metabolic remodelling in late stages of spermatogenesis.
Histone hyperacetylation is thought to drive the replacement of histones by transition proteins that occurs in elongating spermatids after a general shut-down of transcription. The molecular machineries underlying this histone hyperacetylation remain still undefined. Here we focused our attention on...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55767 | biostudies-arrayexpress
TranscriptomicsReceptor-independent ectopic activity of PROLACTIN predicts aggressive lung tumors and indicates HDACi-based therapeutic strategies.
Aim: PROLACTIN (PRL), normally produced by the pituitary gland, acts through its receptor (PRL-R) to initiate a signalling cascade to the genome. PRL can also be produced by cancer cells and become oncogenic by stimulating its receptor following an autocrine or paracrine route. Here we investigated ...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49544 | biostudies-arrayexpress
TranscriptomicsChromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B [Illumina]
The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B variant of hitherto unknown function. Using mous...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-46136 | biostudies-arrayexpress
TranscriptomicsAtad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells [Microarray transcriptomic analysis]
Although the conserved AAA ATPase – bromodomain factor, ATAD2, has been described as a transcriptional co-activator upregulated in many cancers, its function remains poorly understood. Here, using a combination of ChIP-seq, ChIP-proteomics and RNA-seq experiments in embryonic stem cells, we found ...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-69899 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of colonic epithelial cells in adult rats born with intra-uterine growth retardation.
The impact of intra-uterine growth retardation (IUGR) was analyzed on gene expression of the colonic epithelial cells from adults rats fed a standard or a high-fat diet. The hypothesis tested in this study was that IUGR induces sustainable effects on colonocyte transcriptome that may alter further n...
ORGANISM(S): Rattus norvegicus 
2015-11-01 | E-GEOD-65051 | biostudies-arrayexpress
TranscriptomicsRoutine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples. (test samples)
Background: Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16). The aim of this gene expression profiling study was to evaluate to what extent suboptimal...
ORGANISM(S): Homo sapiens 
2011-12-24 | E-GEOD-34714 | biostudies-arrayexpress
TranscriptomicsRoutine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples (training samples)
Background: Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16). The aim of this gene expression profiling study was to evaluate to what extent suboptimal...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-34577 | biostudies-arrayexpress
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