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TranscriptomicsAltered Epigenetic Regulation of Homeobox Genes in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the molecular changes during OSCC carcinogenesis, we performed unbiased, whole genome deep sequencing (RNA-seq) using RNA isolated from cultured, human TERT-immortalized, non-tumorigenic OKF6-TERT1R and OSCC SCC-9 cells. OKF6-TERT1R cells and SCC-9 cells were plated in 10 cm2 t...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51415 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse RARgamma responsive genes in F9 teratocarcinoma cells
We compared the differentially expressed genes between the F9 Wt cells and F9 RAR gamma knock out cells before and after RA treatment. 3 replicates for each conditions. We also identified the RA responsive genes in the F9 Wt cells. Experiment Overall Design: F9 wt cells and F9 RAR gamma knock out ce...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8431 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression changes in mouse tongue squamous cell carcinomas induced by 4-nitroquinoline 1-oxide (4-NQO)
We hypothesized that the expression of many genes are dysregulated during oral cancer carcinogenesis. We examined genome-wide transcript levels in normal mouse tongues and the tongue squamous cell carcinomas induced by 4-NQO. The results will provide important information for the diagnosis, prevent...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54246 | biostudies-arrayexpress
GenomicsAltered DNA Methylation Patterns in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the DNA methylation changes during OSCC carcinogenesis, we utilized cytosine conversion and next generation sequencing based technique- enhanced reduced representation bisulfite sequencing (ERRBS) - to assess DNA methylation in cultured, human TERT-immortalized, non-tumorigeni...
ORGANISM(S): Homo sapiens 
2014-10-28 | E-GEOD-51752 | biostudies-arrayexpress
TranscriptomicsTranscript levels in CCE WT and RARgamma knockout murine embryonic stem cells treated with either all-trans retinoic acid (8 and 24 hr) or with vehicle control
Retinoic acid receptors (RARs) ?, ?, and ? heterodimerize with Retinoid X receptors (RXR) ?, ?, and ? and bind the cis-acting response elements known as RAREs to execute the biological functions of retinoic acid during mammalian development. RAR? mediates the anti-proliferative and apoptotic effects...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-43221 | biostudies-arrayexpress
TranscriptomicsTranscript level in F9 teratocarcinoma WT and RARalpha knockout in presence and absence of all-trans retinoic acid
Retinoic acid receptors (RARs) α, β and γ are key regulators of embryonic development. Hematopoietic differentiation is regulated by RARα, and several types of leukemia show aberrant RARα activity. We demonstrate that RARα plays an important role in cellular memory and imprinting by regulating the C...
ORGANISM(S): Mus musculus 
2011-08-09 | E-GEOD-31280 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of GGT-HIF1aM3 (γ-HIF1αM3, TRACK) kidney cortex
The complete transcriptomes of kidney cortex from 3 TRACK/γ-HIF1αM3 ~15 month old TG+ male mice and 3 age matched TG- C57BL/6 male mice were sequenced on an Illumina HiSeq2000 Sequencer. Examination of complete transcriptome of kidney cortex between TRACK/γ-HIF1αM3 TG+ male mice and TG- C57BL/6 male...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-54390 | biostudies-arrayexpress
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