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UnknownG9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials.
Not available
S-EPMC11976383 | biostudies-literature
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047572 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047533 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
UnknownUse of three-dimensional (3D) optical flow method in mapping 3D anatomic structure and tumor contours across four-dimensional computed tomography data.
Not available
S-EPMC5721534 | biostudies-literature
UnknownExploring the technological acceptance of a mobile learning tool used in the teaching of an indigenous language.
Not available
S-EPMC8189028 | biostudies-literature
UnknownThe stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress.
Not available
S-EPMC11920096 | biostudies-literature
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
ProteomicsRecessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III
A small proportion of 4H (Hypomyelination, Hypodontia and Hypogonadotropic Hypogonadism) or RNA polymerase III (POLR3)-related leukodystrophy cases are negative for mutations in the previously identified causative genes POLR3A and POLR3B. Here, we report eight of these cases carrying recessive mutat...
ORGANISM(S): Homo sapiens (Human) 
2019-10-16 | PXD002154 | Pride
Leukodystrophy Human Rna polymerase iii Polr1c 
UnknownDetection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.
Not available
S-EPMC4832286 | biostudies-literature
UnknownFactors associated with the opposition to COVID-19 vaccination certificates: A multi-country observational study from Asia.
Not available
S-EPMC9113761 | biostudies-literature
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