Sort   by:  
 Page size 
ProteomicsIdentifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics
Mutations in the epidermal growth factor receptor (EGFR) kinase domain occur in 10-30% of lung adenocarcinoma. Leucine to arginine substitution at amino acid position 858 (L858R) accounts for around 50% of EGFR-tyrosine kinase inhibitor (TKI) sensitizing mutations. A second site mutation in the gate...
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001101 | Pride
Nsclc Phosphoproteomics Tki Egfr Adenocarcinoma 
ProteomicsQuantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V
Lung cancer is the leading cause of cancer death both in men and women. Tumor heterogeneity is an impediment to targeted treatment of all cancers, including lung cancer. Here, we sought to characterize changes in tumor proteome and phosphoproteome by longitudinal, prospective collection of tumor tis...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010779 | Pride
Lung adenocarcinoma Proteomic heterogeneity Quantitative mass spectrometry 
ProteomicsA quantitative phosphoproteomic analysis to study the dynamics of tyrosine phosphorylation in EGFR signaling abrogated by TKIs
Lung cancer is the leading cause of cancer death. Mutations in the kinase domain of EGFR, a predominant driver oncogene, such as L858R missense mutation and a series of deletions spanning the conserved sequence 747LREA750, are associated with sensitivity to tyrosine kinase inhibitors (TKIs). However...
ORGANISM(S): Homo sapiens (Human) 
2017-03-29 | PXD004373 | Pride
Nsclc Phosphoproteomics Tki Egfr Adenocarcinoma 
ProteomicsAPOBEC mutagenesis and copy number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors
Intratumor mutational heterogeneity has been documented in primary non-small cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...
ORGANISM(S): Homo sapiens (Human) 
2019-05-07 | PXD012845 | Pride
Proteomics Tumor heterogeneity rapid autopsy 
UnknownPhase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.
Not available
S-EPMC5978471 | biostudies-literature
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsProteogenomic analysis unveils the expression of cancer associated and specific antigen-derived HLA Class ǀ immunopeptides in melanoma and EGFR mutant lung adenocarcinoma
Immunotherapy has shown great therapeutic potential for cancers with high tumor mutational burden (TMB), but much less promise for cancers with low TMB. One primary approach for adoptive lymphocyte transfer-based immunotherapy is to target the somatic mutated peptide neoantigens and cancer testis (C...
ORGANISM(S): Homo sapiens (Human) 
2021-12-07 | PXD019774 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
UnknownMolecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial.
Not available
S-EPMC4356709 | biostudies-literature
OtherIdentifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.
Data from ProteomeXchange, PXD ID: PXD001101. Experiment: pST_SILAC_R1a, file: H3255_pST_SILAC_R1_F4_a.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):340-55 . From the Abstract: {{i}} . We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320007613 | GPMDB
Resource Reanalysis 
Sort   by:  
 Page size