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This pilot study enrolled 9 GWI (Gulf War Illness) cases identified from the Department of Veterans Affairs GWI registry, and 11 sedentary control veterans who had not been deployed to the Persian Gulf and were matched to cases by sex, body mass index (BMI) and age.
We exposed GWI patients and ma...
ORGANISM(S): Homo sapiens 
Long term consequences of combined pyridostigmine bromide and permethrin exposure in C57BL6/J mice using a well characterized mouse model of exposure to these Gulf War agents. Expanding on earlier work, we used orthogonal proteomic approaches to identify pathways that are chronically impacted in the...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-01 | PXD005185 | Pride
Long term consequences of combined pyridostigmine bromide and permethrin exposure in C57BL6/J mice using a well characterized mouse model of exposure to these Gulf War agents. Expanding on earlier work, we used orthogonal proteomic approaches to identify pathways that are chronically impacted in the...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-01 | PXD005198 | Pride
Gulf War Illness (GWI) affects up to one-third of 1990–1991 Gulf War veterans and is associated with chronic low-grade neuroinflammation, yet its cellular substrates remain unclear and targeted pharmacological therapies are still limited. By using hippocampal single-nucleus RNA sequencing (snRNA-seq...
ORGANISM(S): Mus musculus 
2026-07-14 | GSE338196 | GEO
Altered gut microbiome in a mouse model of gulf war illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation
Neuroimmune priming and microglial exhaustion in aged Gulf War Illness mice
Gulf War Illness (GWI) affects up to one-third of 1990–1991 Gulf War veterans and is associated with chronic low-grade neuroinflammation, yet its cellular substrates remain unclear and targeted pharmacological therapies are still limited. By using bulk RNA-seq analyses of whole-brain in an establish...
ORGANISM(S): Mus musculus 
2026-07-14 | GSE338199 | GEO
Cannabidiol reverses neuroimmune priming in aged Gulf War Illness mice
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