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TranscriptomicsGene expression profile of liver tissue in carbon tetrachloride (CCl4)-treated mouse treated with erlotinib
Gene-expression profiles of liver tissue of cabon tetrachloride (CCl4)-treated mouse and the effect of erlotinib Hepatocellular carcinoma (HCC) is the sixth most common solid tumor worldwide and the third leading cause of cancer-related death. Given the lack of successful treatment options, chemopre...
ORGANISM(S): Mus musculus 
2014-02-28 | E-GEOD-27640 | biostudies-arrayexpress
MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
TranscriptomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-29 | E-GEOD-12060 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-58782 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP 8hr]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51173 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [DEX]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51174 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [AFB1]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51171 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51172 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51175 | biostudies-arrayexpress
ProteomicsTWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression
Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived sign...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084273 | MassIVE
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