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TranscriptomicsSuppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) in adult SSc patients. In this study, we aim to assess the downstream effects of anifrolumab and elucidate the role of...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-65336 | biostudies-arrayexpress
UnknownGene-environment correlation: difficulties and a natural experiment-based strategy.
Not available
S-EPMC3778033 | biostudies-literature
TranscriptomicsNatural variation in Arabidopsis thaliana transcriptomes
A major effort is underway to study the natural variation within the model plant species, Arabidopsis thaliana. Much of this effort is focused on genome resequencing, however the translation of genotype to phenotype will be largely effected through variations within the transcriptomes at the sequen...
ORGANISM(S): Arabidopsis thaliana 
2012-05-21 | E-GEOD-38109 | biostudies-arrayexpress
UnknownChondroitin polymerizing factor (CHPF) promotes development of malignant melanoma through regulation of CDK1.
Not available
S-EPMC7329816 | biostudies-literature
MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
TranscriptomicsTransposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata [RNA-Seq]
Transposable elements (TEs) are often the primary determinant of genome size differences among eukaryotes. In plants, the proliferation of TEs is countered through epigenetic silencing mechanisms that prevent transposition. Recent studies using the model plant Arabidopsis thaliana have revealed that...
ORGANISM(S): Arabidopsis lyrata 
2011-02-11 | E-GEOD-24571 | biostudies-arrayexpress
MetabolomicsLC-HRMS Metabolomics for Untargeted Diagnostic Screening in Clinical Laboratories: A Feasibility Study
Today's high-resolution mass spectrometers (HRMS) allow bioanalysts to perform untargeted/global determinations that can reveal unexpected compounds or concentrations in a patient’s sample. This could be performed for preliminary diagnosis attempts when usual diagnostic processes and targeted ...
2019-06-06 | MTBLS476 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
ProteomicsMolecular characterization of the brain peri-infarct region after post-stroke MANF administration
Shotgun proteomics analysis of brain peri-infarct region from rats subjected to ischemic stroke and treated with AAV-MANF or a control AAV-eGFP, compared to each other and to rats subjected to a sham operation.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2019-05-28 | MSV000083869 | MassIVE
MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
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