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MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Untargeted assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prosta...

2023-04-17 | MTBLS6039 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
TranscriptomicsExpression profiling of B.subtils SMY wild-type, (p)ppGpp0, M-NM-^TcodY (p)ppGpp0 and guaB- (p)ppGpp0 cells upon amino acid starvation (RHX) or guanosine (Guo) treatment.
The nucleotide (p)ppGpp is crucial for viability during amino acid limitation in bacteria, yet how it accomplishes this remains unknown. We found that the absence of (p)ppGpp in Bacillus subtilis cells leads to multiple amino acid auxotrophy, and that (p)ppGpp allows for prototrophy by reducing GTP ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-01 | E-GEOD-41501 | biostudies-arrayexpress
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
TranscriptomicsDistinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel
Background: Current protocols for the treatment of ovarian cancer include combination chemotherapy with a platinating agent and a taxane. However, many patients experience relapse of their cancer and the development of drug resistance is not uncommon, making successful second line therapy difficult ...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-39337 | biostudies-arrayexpress
UnknownAssociation between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis.
Not available
S-EPMC10566167 | biostudies-literature
ProteomicsProteomics Analysis of the Mechanism of AMP-17 against Candida albicans
Candida albicans is the most common human fungal pathogen in immunocompromised individuals. With the emergence of clinical fungal resistance, there is an urgent demand to develop novel antifungal agents. The antibacterial peptide (AMP) is an important component in the innate immune system and has a ...
ORGANISM(S): Candida albicans (Yeast) 
2019-10-23 | PXD015469 | Pride
Candida albicans Amp-17 Antimicrobial peptides Proteomic Tmt- labeling Mechanism 
UnknownPreadaptation and post-introduction evolution facilitate the invasion of Phragmites australis in North America.
Not available
S-EPMC4278810 | biostudies-literature
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
UnknownA new species of <i>Diglyphus</i> Walker (Hymenoptera, Eulophidae) from China, with notes on its biology and a key to the Chinese species.
Not available
S-EPMC12595511 | biostudies-literature
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