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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsProteomic profiling reveals the molecular control of oocyte maturation
Meiotic maturation is an intricate and precisely regulated process orchestrated 32 by various pathways and numerous proteins. However, little is known about the 33 proteome landscape during oocytes maturation. Here, we obtained the temporal 34 proteomic profiles of mouse oocytes during in vivo ma...
ORGANISM(S): Mus Musculus 
PXD034150 |
ProteomicsSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are new identified symptoms of COVID‐19, and both of these are related to cilia dysfunction. However, the pathological me...
ORGANISM(S): Homo Sapiens 
2022-02-23 | PXD031842 |
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