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TranscriptomicsmicroRNA expression in murine hematopoietic stem cells
MicroRNAs influence hematopoietic differentiation, but little is known about their effects on the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential for stem cell persistence in vivo and a specific microRNA, miR-125a controls the size of the stem cell population ...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-22450 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of cells of different cycling speed during Yamanaka reprogramming
Reprogramming somatic cells to induced pluripotency by Yamanaka factors is usually slow and inefficient, and is thought to be a stochastic process. We identified a privileged somatic cell state, from which acquisition of pluripotency could occur in a non-stochastic manner. Subsets of murine hematopo...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53074 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cells NF639 cells original population vs EGCG-resistant population
Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer leads to autophosphorylation of the receptor, and induction of multiple downstream signaling pathways including Akt kinase to NF-B cascade that is associated with poor prognosis. Previously, we demonst...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4140 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling data of mouse bone marrow samples four days post 5-FU treatment versus untreated controls
To identify miRNAs that regulate hematopoietic response after 5-FU-induced injury, we analyzed miRNA expression changes in bone marrow cells from mice with or without 5-FU treatment. Global miRNA expression profiling of the 5-FU and untreated cohorts showed that 92 miRNAs (among 168 that passed the ...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-39211 | biostudies-arrayexpress
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