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Transcriptomics16S rRNA gene sequence analysis of feces samples from rats treated with paclitaxel or vehicle controls
To address the role of gut microbiota in the development of paclitaxel-induced peripheral neuropathy (PIPN), we performed 16S rRNA sequencing analysis of feces samples at 14 days and 28 days after the initiation of paclitaxel or vehicle injections.
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13426 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat dorsal root ganglions treated with paclitaxel against untreated controls
L4-L5 segment dorsal root ganglion (DRG) samples from controls and the paclitaxel-induced peripheral neuropathy (PIPN) rats were collected at day 14 after the initiation of paclitaxel treatment. Paclitaxel and vehicle were administered intraperitoneally at 2 mg/kg for four consecutive days at a fina...
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13430 | biostudies-arrayexpress
MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsHuman CCDC114-mutant patient derived air-liquid interface (ALI) organoids proteome
In this experiment we investigate the different expressed proteins between healthy control ALI organoids and CCDC114-mutant ALI organoids.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD064456 | Pride
Human Organoids Airway Ccdc114 
UnknownThioparib Inhibits Homologous Recombination Repair, Activates the Type-I IFN Response, and Overcomes Olaparib Resistance
Not available
S-SCDT-10_15252-EMMM_202216235 | biostudies-other
UnknownA Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Not available
S-EPMC7121492 | biostudies-literature
ProteomicsDNA-guided Photoactivatable Probe-based Chemical Proteomics Reveals the Reader Protein of mRNA Methylation
We report a DNA templated chemistry and photo-crosslinking based method to detect the readers of mRNA modification. By use of N6-methyladenosine (m6A), we illustrated that this method can be successfully utilized for labelling and enriching the readers of mRNA modification, as well as for the discov...
ORGANISM(S): Homo Sapiens 
2020-05-30 | PXD019480 |
ProteomicsIntegrated Omics in Drosophila Uncover Circadian Kinases
Most organisms on the earth exhibit circadian rhythms in behavior and physiology, which are driven by endogenous clocks. Phosphorylation plays a central role in timing the clock, but how this contributes to overt rhythms is unclear. Here we conducted phosphoprotemoics in conjunction with transcripto...
ORGANISM(S): Drosophila Melanogaster 
2018-05-31 | PXD009887 |
ProteomicsHuman HNF1A KI mice liver proteome analysis
Nonalcoholic fatty liver disease (NAFLD) is a pathological condition caused by excessive fat accumulation in liver. HNF1A is the pathogenic cause of hepatocellular adenoma and HCC. It is an important transcription factor in liver. We constructed a knock-in mice expressing a human dominant negative H...
ORGANISM(S): Mus Musculus 
2023-03-02 | PXD040561 |
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