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ProteomicsCharacterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model
ALS is a devastating motor neuron disease. Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification has been found to affect the processing of several important proteins implicated in ALS. However, the O-GlcNAcylated proteome remains unexplored during ALS progression. Herein, we probed the dyn...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059664 | Pride
Amyotrophic lateral sclerosis (als) Sod1-g93a mice O-linked β-n-acetylglucosamine (o-glcnac) Lc-ms/ms 
ProteomicsEndothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis
Using proteomic analysis, we revealed that 110 proteins were differentially expressed in NSC34-hSOD1G93A cells after ET-1 treatment in our experiments, of which 54 were up-regulated and 56 were down-regulated. Bioinformatics analysis showed that the differentially expressed proteins (DEPs) were prim...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037555 | Pride
Lc-ms/ms analysis 
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