Sort   by:  
 Page size 
TranscriptomicsTranscriptional profiling of the tuberculin skin test in healthy volunteers and in rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy
Anti-TNF therapy has transformed the management of rheumatoid arthritis (RA); however little is known about its effects on cell mediated immune responses and TNF-inducible activity at the site of inflammation. Here, we used the tuberculin skin test (TST) as a standardised in vivo human challenge mod...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5093 | biostudies-arrayexpress
TranscriptomicsWhole blood transcriptional profiling of healthy volunteers and rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy after ex vivo whole blood stimulation with TNF
We tested the hypothesis that anti-tumor necrosis factor (TNF) therapy reduces TNF-inducible gene expression in blood. Whole peripheral blood from healthy volunteers and rheumatoid arthritis patients (treated with the monoclonal anti-TNF antibody adalimumab, the soluble TNF receptor etanercept or th...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5094 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
Sort   by:  
 Page size