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TranscriptomicsRegulators of NRAS-mediated transformation and melanoma tumor maintenance
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-69933 | biostudies-arrayexpress
TranscriptomicsOncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells
Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of this silencing in oncogenesis is not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces silencing...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-39292 | biostudies-arrayexpress
TranscriptomicsTranscriptional targets of oncogenic RAS proteins that mediate their ability to induce cellular transformation
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-62827 | biostudies-arrayexpress
UnknownA machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys.
Not available
S-EPMC9040372 | biostudies-literature
UnknownInsights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.
Not available
S-EPMC8118652 | biostudies-literature
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