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We investigated genome-wide DNA methylation of NeuN+ and NeuN- fractions in three brain regions using comprehensive high throughput arrays for relative methylation (CHARM). We isolated genomic DNA from cell-sorted post-mortem brains using NeuN antibody and hybridized to Nimblegen microarrays (091020...
ORGANISM(S): Homo sapiens 
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 

This study involved evaluation of the tissue associated microbiome of the ileal pouch following surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted an...

Macrophages are a major cellular component of all inflammatory situations, generating proinflammatory cytokines such as TNF-alpha, IL-1, and IL-6 that are central to the initiation and maintenance of inflammation. To determine whether the tumor suppressor ARF plays a role in inflammatory gene expres...
ORGANISM(S): Mus musculus 
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