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TranscriptomicsGene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance
Background and Aims: Viral clearance during acute hepatitis C virus (HCV) infection is associated with the induction of potent antiviral T-cell responses. Since dendritic cells (DC) are essential in the activation of primary T-cell responses our goal was to analyze gene expression in DC from patient...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-65123 | biostudies-arrayexpress
TranscriptomicsIdentification of tissue microRNAs predictive of sutinib activity in patients with metastatic renal cell carcinoma
Purpose: To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell carcinoma (MRCC) and to validate them in a cellular model. Selected microRNAs were studied in serum from MRCC patients and healthy individuals. Methods: We screened 673 microRNAs using TaqM...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-37766 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of binding sites of Evi1 in human myeloid cell lines
The EVI1 gene codes for a transcription factor with important roles in development and leukemogenesis. Overexpression of EVI1 in acute myeloid leukemia (AML) is one of the worst prognostic factors in patients with and without 3q26 rearrangements. Evi1 acts in several pathways through the interaction...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-16238 | biostudies-arrayexpress
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