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TranscriptomicsForm deprivation modulates retinal neurogenesis in primate experimental myopia
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining a...
ORGANISM(S): Macaca mulatta 
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines.
To identify altered pathways in SCA28 LCLs, we performed a whole genome expression profiling, based on Affymetrix Human Genome U133A 2.0 Chip Array, on LCLs from four unrelated patients, each carrying a different AFG3L2 mutation. Gene expression profiling of 4 patients and 6 healthy controls
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-42406 | biostudies-arrayexpress
TranscriptomicsGene expression in spinal cord neurons grown on polyornithine or on carbon nanotube (CNT)-based substrates
Carbon nanotubes are cylindrically-shaped carbon nanostructures, made up of layers of graphene rolled onto themselves, with diameters similar to those of neuronal processes. In the last decade, CNT have been used as biocompatible growing substrates for neuronal attachment, differentiation and growth...
ORGANISM(S): Rattus norvegicus 
2013-08-05 | E-GEOD-27212 | biostudies-arrayexpress
TranscriptomicsPivotal role of HMGA1 gene signature in highly metastatic breast cancer
Analysis of MDA-MB-231 breast cancer cells depleted for High Mobility Group A1 (HMGA1) using siRNA. HMGA1 is involved in invasion and metastasis in breast cancer cells. Results identify the specific transcriptional program induced by HMGA1 in highly metastatic breast cancer cells. MDA-MB-231 cells w...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-35525 | biostudies-arrayexpress
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