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MetabolomicsMulti-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foo...
2020-11-19 | MTBLS138 | MetaboLights
MetabolomicsIntestinal TM6SF2 Protects Against Metabolic Dysfunction-associated Steatohepatitis through the Gut-Liver Axis

Transmembrane-6 superfamily member 2 (TM6SF2) regulates hepatic fat metabolism and is closely associated with metabolic dysfunction-associated steatohepatitis (MASH). MASH involves genetic predisposition and gut microbiota alteration, yet the role of host-microbes interaction in disease developme...

2024-10-08 | MTBLS11004 | MetaboLights
MetabolomicsMicroplastics Induce Damage to Cattle and Potential Health Risks Through Microbial Mediation: A Rumen Microbiota-Gut-Liver Axis Perspective_blood

Microplastics pollution is prevalent in livestock environments, especially in ruminant feed. Exposure to microplastics can damage the gastrointestinal barrier, alter microbiota, and lead to organ damage. Despite its impact on cattle farming and potential human health risks, the effects of microp...

2025-09-08 | MTBLS12958 | MetaboLights
MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
MetabolomicsMicroplastics Induce Damage to Cattle and Potential Health Risks Through Microbial Mediation: A Rumen Microbiota-Gut-Liver Axis Perspective_Rumen Fluid

Microplastics pollution is prevalent in livestock environments, especially in ruminant feed. Exposure to microplastics can damage the gastrointestinal barrier, alter microbiota, and lead to organ damage. Despite its impact on cattle farming and potential human health risks, the effects of micropl...

2025-09-08 | MTBLS12959 | MetaboLights
MetabolomicsIntegrated multi-omics reveals Enterococcus faecalis JM263 alleviates high-concentrate diet-induced hepatic injury via the gut-liver axis in goats

This dataset contains raw liquid chromatography-tandem mass spectrometry (LC-MS/MS) data derived from the liver tissues of goats (Capra hircus). The purpose of this study is to explore the metabolic regulatory mechanism of the probiotic Enterococcus faecalis JM263 in goats fed a high-concentrate ...

2026-01-15 | MTBLS13688 | MetaboLights
MetabolomicsRoyal jelly and 10-hydroxy-2-decenoic acid mitigate alcoholic fatty liver disease in mice via the gut-microbiota-metabolite axis

Royal jelly (RJ) and its signature bioactive compound, 10-hydroxy-2-decenoic acid (10-HDA), are believed to possess hepatoprotective properties. However, their protective effects and underlying mechanisms against alcoholic fatty liver disease (AFLD) remain unclear. In the present study, we integr...

2026-05-14 | MTBLS14067 | MetaboLights
MetabolomicsXuezhikang Ameliorating Non-Alcoholic Fatty Liver Disease via the Gut Microbiota-Metabolite-Ferroptosis Axis: A Multi-Omics Study
Objective: This study investigated the therapeutic mechanism by which Xuezhikang (XZK) alleviates non-alcoholic fatty liver disease (NAFLD) in mice, with a specific focus on the interplay between the gut microbiota, metabolic alterations, and hepatic ferroptosis. Methods: An NAFLD mouse model was in...
2026-06-16 | MTBLS14743 | MetaboLights
MetabolomicsEffects of Leuconostoc lactis on the antioxidant ability and indole-3-acetaldehyde metabolism via regulating the gut microbiota-liver axis in aged laying hens

Lactobacillus has antioxidant properties that may benefit poultry production. However, there is no systematic research on antioxidant of Lactobacillus strain and its effects on regulating nutrient metabolism in aged laying hens. This study investigated the influence of Leuconostoc lactis on produ...

2025-09-09 | MTBLS12964 | MetaboLights
ProteomicsGut-liver axis calibrates intestinal stem cell fitness via PEDF
The gut and liver have been recognized to mutually communicate through the biliary tract, portal vein and systemic circulation, but it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy, transcriptomics and proteomics profiling, we identified pigment epithel...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-03 | MSV000091409 | MassIVE
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