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ProteomicsIntegrative Structural Characterization of the Human Canonical and Non-canonical Cop9 Signalosome Complexes
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that functions as a deneddylase to inactivate Cullin-RING E3 ligases for controlling protein ubiquitination. CSN possesses structural flexibility that is important for its activation upon binding to a diverse array of CRLs. Th...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD014673 | Pride
Mass spectrometry Sulfoxided based cross-linkers Cross-linking Intergrative modeling platform (imp) Ms-cleavable Cop9 signalosme 
ProteomicsEnabling Photoactivated Cross-linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-cleavable Cross-linkers
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions non-targetable by specific chemistries remain ...
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-07 | PXD022690 | Pride
26s proteasome Photocross-linking Sdaso Bsa 
TranscriptomicsTranscription profiling of human sensitive and resistant tumours identify gene expression patterns in primary breast-cancer specimens that might predict response to taxanes.
These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume.
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-349 | biostudies-arrayexpress
UnknownThe Vibrio cholerae minor pilin TcpB mediates uptake of the cholera toxin phage CTXφ.
Not available
S-EPMC6816102 | biostudies-literature
TranscriptomicsTranscription profiling of human breast cancer patients sensitive to docetaxel
These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-350 | biostudies-arrayexpress
UnknownThe curious case of a heterozygous loss-of-function <i>PSEN1</i> variant associated with early-onset Alzheimer's disease.
Not available
S-EPMC12537781 | biostudies-literature
UnknownA phase I/II dose-escalation study investigating all-oral ixazomib-melphalan-prednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma.
Not available
S-EPMC6119151 | biostudies-literature
UnknownScope and Consistency of Cancer Outcomes Reported in Randomized Trials in Kidney Transplant Recipients.
Not available
S-EPMC9939355 | biostudies-literature
UnknownCritically Important Cancer Outcomes to Report in Kidney Transplant Trials.
Not available
S-EPMC12545558 | biostudies-literature
UnknownClinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium.
Not available
S-EPMC10511777 | biostudies-literature
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