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A whole body knockout mouse was generated by deleting the 1st exon and the 620 bp immediately upstream of the gene encoding the long non-coding RNA, Pax6os1 via CRISPR.
ORGANISM(S): Mus musculus 
Wnt signaling, which drives the rapid self-renewal of the gut epithelium is causally associated with intestinal neoplasia. Here we show that CKIalpha is a activation depends on p53 and p21Waf1/Cip1: CKIα ablation provokes activation of p53 and p21, which assume a pivotal role in suppressing invasiv...
ORGANISM(S): Mus musculus 
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