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GenomicsRNAseq PC3 DMSO vs GW3965
RNAseq PC3 DMSO vs GW3965
PRJNA1029015 | ENA
TranscriptomicsBroad-Spectrum Therapeutic Suppression of Metastatic Melanoma Through Nuclear Hormone Receptor Activation
Melanoma metastasis is a devastating outcome in need of novel preventive therapies. We provide pharmacologic, nolecuar, and genetic evidence establishing the liver-X nuclear hormone receptor (LXR) as a therapeutic target in melanoma. Molecular and genetic experiments revealed these effects to be med...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-48782 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of genes in AML12 cells treated with Palmitic acid, LXR lingand (GW3965) and Ulk1 siRNA
Transcriptional regulation of genes in AML12 cells treated with Palmitic acid, LXR lingand (GW3965) and Ulk1 siRNA shows differential effect of Ulk1 KD on LXr responsive genes AML-12 cells co-treated with 0.75mM PA+/- 10µM GW3965 for 24 h +/- Ulk1 SiRNA
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-74059 | biostudies-arrayexpress
TranscriptomicsThe effect of GW3965 and dexamethasone on gene expression of rat livers
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase) a key enzyme of gluconeogenesis, and suppress the immune system which makes them one of the most important therapeutic agents in th...
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-29912 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of GW3965-responsive genes in 4 different breast cancer cell lines, MCF-7, T-47D, SK-BR-3, and MDA-MB-231
Analysis of differentially expressed genes in response to the LXR agonist GW3965 in the MCF-7, T-47D, SK-BR-3, and MDA-MB-231 breast cancer cell lines. It was previously reported that GW3965 has antiproliferative effects on these 4 different breast cancer cell lines. In the present study, we additi...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-34987 | biostudies-arrayexpress
UnknownABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke.
Not available
S-EPMC5263181 | biostudies-literature
GenomicsBulk RNA-seq of intestinal organoids upon treatment with LXR agonist GW3965
Bulk RNA-seq of intestinal organoids upon treatment with LXR agonist GW3965
PRJNA638894 | ENA
TranscriptomicsmiRNA expression screening in Liver X Receptor (NR1H3) agonist (GW3965) -treated differentiated Caco-2/TC7 cells
Differentiated human enterocytic Caco-2/TC7 cells grown on transwell were incubated with LXR agonist GW3965 (5µM) or Vehicle DMSO (1:2000 ; vol:vol) for 48 hours. Total RNA were extracted using mirVana miRNA Isolation Kit (life technologies) then processed with Flash Tag Biotin HSR kit (Affymetrix) ...
ORGANISM(S): Homo sapiens 
2016-06-03 | E-MTAB-3675 | biostudies-arrayexpress
GenomicsIntestine-specific activation of LXR via low-dose oral administration of GW3965
Intestine-specific activation of LXR via low-dose oral administration of GW3965
PRJNA705703 | ENA
UnknownThe liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.
Not available
S-EPMC3547922 | biostudies-literature
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