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GenomicsThe RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner
Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in different species implicates RNA and RNA-binding proteins as regulators of chromatin insulator activ...
ORGANISM(S): Drosophila melanogaster 
2014-04-18 | E-GEOD-51462 | biostudies-arrayexpress
ProteomicsNURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers and promoters to regulate gene expression. In Drosophila, the gypsy chromatin insulator complex consists of three core proteins: CP190, Su(Hw), and Mod(mdg4)67...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-14 | PXD032165 | Pride
Mass spec Nurf301 Drosophila Gypsy insulator 
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
GenomicsNURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
PRJNA814692 | ENA
GenomicsNURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers and promoters to regulate gene expression. In Drosophila, the gypsy chromatin insulator complex consists of three core proteins: CP190, Su(Hw), and Mod(mdg4)67...
ORGANISM(S): Drosophila melanogaster 
2022-06-28 | GSE198361 | GEO
GenomicsRNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function
Chromatin insulators and Polycomb group (PcG) complexes control nuclear organization to effect changes in gene expression. In Drosophila, RNA silencing pathways influence long range interactions mediated by PcG proteins and nuclear localization of the gypsy insulator; however, the underlying mechan...
ORGANISM(S): Drosophila melanogaster 
2011-08-15 | E-GEOD-22623 | biostudies-arrayexpress
GenomicsEffete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [ChIP-Seq]
Effete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [ChIP-Seq]
PRJNA1018521 | ENA
GenomicsEffete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [RNA-Seq]
Effete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [RNA-Seq]
PRJNA1018520 | ENA
GenomicsThe tumor suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements
In Drosophila, defects in asymmetric cell division can result in the formation of stem cell derived tumors. Here, we reveal a different mechanism that can result in the formation of very similar terminal brain tumor phenotypes. We demonstrate that brain tumors in l(3)mbt mutants originate from overp...
ORGANISM(S): Drosophila melanogaster 
2011-08-29 | E-GEOD-29206 | biostudies-arrayexpress
GenomicsEffete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [ChIP-Seq]
Chromatin insulators demarcate the genome into distinct transcriptional domains and contribute to higher-order genome organization. In Drosophila, Su(Hw), CP190, and Mod(mdg4)67.2 are core protein components of the gypsy insulator complex. Multimerization of these core components contributes to form...
ORGANISM(S): Drosophila melanogaster 
2026-02-27 | GSE243452 | GEO
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