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GenomicsMapping of somatic linker histone H1 variants in T47D-MTVL cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49334 | biostudies-arrayexpress
TranscriptomicsMapping of somatic linker histone H1 variants in T47D-MTVL and HeLa cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49333 | biostudies-arrayexpress
ProteomicsSite-specific ubiquitylation acts as a regulator of linker histone H1
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. While this process is well studied for core histones and many of their PTMs, this is not the case for linker histone H1 in general and its ubiquitylation in part...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD025258 | Pride
Epigenetics Linker histone h1 Ubiquitin Posttranslational modification (ptm) Histone code Chromatin 
ProteomicsThe functional interactome of site-specifically ubiquitylated linker histone H1
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. While this process is well studied for core histones and many of their PTMs, this is not the case for linker histone H1 in general and its ubiquitylation in part...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD020686 | Pride
Epigenetics Linker histone h1 Ubiquitin Posttranslational modification (ptm) Histone code Chromatin 
ProteomicsInteractome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2
Post-translational modifications (PTMs) of histones have fundamental effects on chromatin structure and function. While the impact of PTMs on the function of core histones are increasingly well understood, this is much less the case for modifications of linker histone H1, which is at least in part d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-02 | PXD040236 | Pride
Affinity enrichment : proteomics Post-translational modification Chromatosome Chemical biology Linker histone 
GenomicsGenomic distribution of human histone H1 subtypes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49345 | biostudies-arrayexpress
ProteomicsThe interactome of site-specifically acetylated linker histone H1
Linker histone H1 plays a key role in chromatin organization and maintenance, however, our knowledge of the regulation of H1 functions by its posttranslational modifications (PTMs) is very limited. In this study, we report on the generation of homogeneously and site-specifically mono- and di-acetyla...
ORGANISM(S): Homo sapiens (Human) 
2021-07-09 | PXD025832 | Pride
Epigenetics Acetylation Linker histone h1 Posttranslational modification (ptm) Histone code Chromatin Interactions Genetic code expansion Affinity purification-mass spectrometry (ap-ms) 
UnknownOrganoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors.
Not available
S-EPMC8872386 | biostudies-literature
UnknownInvestigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases.
Not available
S-EPMC12363342 | biostudies-literature
ProteomicsHuman Histone Fragments Display Antibacterial Properties against Pseudomonas aeruginosa
Differential proteomic experiment using Pseudomonas aeruginosa in the presence and the absence of Human Histone Fragments.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-09-14 | PXD080063 | Pride
Human histones Antibacterial activity H1.2 peptide Neutrophil extracellular traps (nets) Outer membrane biogenesis Immunomodulatory effects Antimicrobial peptides (amps) Pseudomonas aeruginosa 
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