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ProteomicsProfiling of ADAM12S regulated proteins in H1688 cells
In this project, we used SILAC quantitative proteomics to identify proteins that are differentially regulated by the short secreted form of A Disintegrin And Metalloproteinase 12, ADAM12S, in a small cell lung cancer cell line H1688. The aim of this study is to discover the proteins that are respons...
ORGANISM(S): Homo sapiens (Human) 
2021-02-15 | PXD013242 | Pride
Human Silac quantification Orbitrap elite H1688 Adam12s Lc-ms/ms 
TranscriptomicsNCI-H1688 cells treated with natural compounds(sanguinarine chloride, cepharanthine and evodiamine), or (+)-JQ-1, or panobinostat, or sanguinarine chloride in combination with panobinostat or (+)-JQ-1.
Purpose: we used next generation sequencing to analyze gene expression profiles of NCI-H1688 treated with different drugs and elaborated the combinatorial effect of sanguinarine chloride and panobinostat or (+)-JQ-1.The goals of this study are to compare the drug effect and find out the resonally sy...
ORGANISM(S): Homo sapiens 
2021-08-31 | GSE182821 | GEO
GenomicsNCI-H1688 cells treated with natural compounds(sanguinarine chloride, cepharanthine and evodiamine), or (+)-JQ-1, or panobinostat, or sanguinarine chloride in combination with panobinostat or (+)-JQ-1.
NCI-H1688 cells treated with natural compounds(sanguinarine chloride, cepharanthine and evodiamine), or (+)-JQ-1, or panobinostat, or sanguinarine chloride in combination with panobinostat or (+)-JQ-1.
PRJNA757981 | ENA
TranscriptomicsEffect of depletion of KLF9 on gene expression of small cell lung cancer cells in vitro
To investigate the function of KLF9 in the regulation of small cell lung cancer, we established SCLC cell lines (NCI-H146, NCI-H1688) and knocked down KLF9 with shRNA.
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE299679 | GEO
UnknownTanshinone IIA inhibits proliferation and migration by downregulation of the PI3K/Akt pathway in small cell lung cancer cells.
Not available
S-EPMC10829381 | biostudies-literature
TranscriptomicsStudying the gene expression of FOXM1- depleted SCLC cell lines by RNA-seq
Purpose: Small cell lung cancer (SCLC) continues to cause poor clinical outcomes due to limited advances in sustained treatments for rapid cancer cell proliferation and progression. The transcriptional factor Forkhead Box M1 (FOXM1) regulates cell proliferation, tumor initiation and progression in m...
ORGANISM(S): Homo sapiens 
2022-05-01 | GSE174462 | GEO
GenomicsEffect of depletion of KLF9 on gene expression of small cell lung cancer cells in vitro
Effect of depletion of KLF9 on gene expression of small cell lung cancer cells in vitro
PRJNA1275993 | ENA
UnknownNitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Not available
S-EPMC9524076 | biostudies-literature
GenomicsStudying the gene expression of FOXM1- depleted SCLC cell lines by RNA-seq
Studying the gene expression of FOXM1- depleted SCLC cell lines by RNA-seq
PRJNA730017 | ENA
UnknownACT001 Suppresses the Malignant Progression of Small-Cell Lung Cancer by Inhibiting Lactate Production and Promoting Anti-Tumor Immunity.
Not available
S-EPMC11868026 | biostudies-literature
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