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TranscriptomicsIdentification and characterization of two novel primate-specific histone H3 variants H3.X and H3.Y
Nucleosomal incorporation of specialized histone variants is an important mechanism to generate different functional chromatin states. Here we report the identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Their mRNAs are found in certain human cell ...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-22415 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana
Nucleosomes package eukaryotic DNA and are composed of four different histone proteins, H3, H4, H2A and H2B. Histone H3 has two main variants, H3.1 and H3.3, which show different genomic localization patterns in animals. We profiled H3.1 and H3.3 variants in the genome of the plant Arabidopsis thali...
ORGANISM(S): Arabidopsis thaliana 
2012-03-05 | E-GEOD-34840 | biostudies-arrayexpress
ProteomicsMind Your Spectra: Points to be Aware of when Validating the Identification of Isobaric Histone Peptidoforms
Mass spectrometry (MS) is now well recognized as a powerful technique to identify and quantify post-translational modifications (PTMs), overcoming many of the limitations of antibody-based methods. Histones, which play a central role in all DNA-templated processes, are regulated by a wealth of dynam...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD057347 | Pride
Histone h3 variants Acylations Overpropionylation Isobaric peptides 
GenomicsMapping of somatic linker histone H1 variants in T47D-MTVL cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49334 | biostudies-arrayexpress
TranscriptomicsMapping of somatic linker histone H1 variants in T47D-MTVL and HeLa cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49333 | biostudies-arrayexpress
GenomicsDUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (CUT&RUN)
DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (CUT&RUN)
PRJNA489182 | ENA
GenomicsDUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (RNA-seq)
DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression (RNA-seq)
PRJNA489184 | ENA
GenomicsFactors influencing in vivo deposition of histone variants H3.1 and H3.3
Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA histone chaperones. Impairing replicative H3.1 incorporation via CAF-1 enables an alternative H3.3 depos...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-31794 | biostudies-arrayexpress
GenomicsDistribution of total histone variants H3.1 and H3.3 in pluripotent mouse embryonic stem cells (mESCs) and in vitro differentiated neuronal precursor cells (NPCs)
We profiled the enrichment of the replicative H3.1 and non-replicative H3.3 histone variants using the SNAP-seq assay previously developed in the team (Gatto et al., 2022, Forest et al., 2023). We used KH2 mouse embryonic stem cells (mESCs) bearing doxycycline-inducible H3.1/H3.3-SNAP, which were ex...
ORGANISM(S): Mus musculus 
2025-04-24 | E-MTAB-14240 | biostudies-arrayexpress
ProteomicsQuantitative middle-down MS analysis of histone H3 proteoforms throughout lifespan in mice
Replication-independent deposition of histone variant H3.3 into chromatin is essential for many biological processes, including development, oogenesis and nuclear reprogramming. Unlike replication-dependent H3.1/2 isoforms, H3.3 is expressed throughout the cell cycle and becomes enriched in postmito...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-28 | PXD005300 | Pride
Histone modification landscape C57bl/6 mice H3 variants Middle-down ms 
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