Sort   by:  
 Page size 
UnknownTackling aspecific side reactions during histone propionylation: The promise of reversing overpropionylation.
Not available
S-EPMC5096241 | biostudies-literature
ProteomicsMind Your Spectra: Points to be Aware of when Validating the Identification of Isobaric Histone Peptidoforms
Mass spectrometry (MS) is now well recognized as a powerful technique to identify and quantify post-translational modifications (PTMs), overcoming many of the limitations of antibody-based methods. Histones, which play a central role in all DNA-templated processes, are regulated by a wealth of dynam...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD057347 | Pride
Histone h3 variants Acylations Overpropionylation Isobaric peptides 
ProteomicsBoth L-lactyl and D-lactyl enantiomers modify histones in mouse testis
Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues. This modification exists as two enantiomers, L- a...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-01 | PXD070921 | Pride
Lysine lactylation Histones Targeted proteomics 
ProteomicsComplete loss of H3K9 methylation dissolves mouse heterochromatin organization
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp. We used m...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-27 | PXD018175 | Pride
Repeat silencing Heterochromatin organization Histone methyltransferases Proteomic quantification of h3k9 methylation Genome stability 
ProteomicsDeciphering the interplay of aflatoxin B1 and Epstein-Barr virus on the histone landscape in Burkitt Lymphoma cells
Aflatoxin B1 (AFB1), a potent dietary carcinogen, and Epstein-Barr virus (EBV), an oncogenic virus, are both implicated in cancer development, particularly in endemic regions. However, the combined effects of AFB1 exposure and EBV infection on the epigenetic landscape remain poorly understood. This ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD060719 | Pride
Human Epstein-barr virus Aflatoxin b1 Hptms Burkitt lymphoma cells Lc-ms/ms 
ProteomicsMicro-topographies induce epigenetic reprogramming and quiescence in human mesenchymal stem cells
Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression, and cell identity, surface topography can control cell phenotype. This study explores how surface topography influences nuclear morphology, histone modifications, ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-03 | PXD037954 | Pride
Nucleus Epigenetics Biomaterials Mesenchymal stem cells Mechanobiology Dda 
ProteomicsThe PRC1 and PRC2 proximal interactome: the link between H4ac an H3K27me3
Polycomb Repressive Complexes PRC1 and PRC2 play a crucial role in silencing lineage-specific genes during early embryogenesis. To provide new insights in polycomb biology, we profiled the proximal interactome (proxeome) of the catalytic subunits RNF2 (PRC1) and EZH2 (PRC2) in mouse embryonic stem c...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-25 | PXD048246 | Pride
H3k27me3 Ptms Prc1 Prc2 H4ac Histones Lc-ms/ms 
ProteomicsLarge scale toxicoepigenetics on histones: a mass spectrometry-based screening assay applied to developmental toxicity
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds on protein expression through heritable, non-genetic mechanisms, such as histone post-translational modifications (hPTMs). Due to substantial progress in the large-scale study of hPTMs, integration into the fie...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026468 | Pride
Histone post-translational modifications Drug screening Toxicoepigenetics Developmental toxicity Lc-ms/ms 
ProteomicsComprehensive Histone Epigenetics (CHEpi): A mass spectrometry based screening assay to measure epigenetic toxicity
Epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large scale analysis of histone posttranslational modifications (hPTM...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-10-12 | PXD019652 | Pride
Histone post-translational modifications Drug safety Toxicoepigenetics Pharmacoepigenetics Screening Proteomics Lc-ms/ms 
Sort   by:  
 Page size