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UnknownToxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science.
Not available
S-EPMC9290111 | biostudies-literature
ProteomicsLarge scale toxicoepigenetics on histones: a mass spectrometry-based screening assay applied to developmental toxicity
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds on protein expression through heritable, non-genetic mechanisms, such as histone post-translational modifications (hPTMs). Due to substantial progress in the large-scale study of hPTMs, integration into the fie...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026468 | Pride
Histone post-translational modifications Drug screening Toxicoepigenetics Developmental toxicity Lc-ms/ms 
UnknownA large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity.
Not available
S-EPMC8786925 | biostudies-literature
ProteomicsComprehensive Histone Epigenetics (CHEpi): A mass spectrometry based screening assay to measure epigenetic toxicity
Epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large scale analysis of histone posttranslational modifications (hPTM...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-10-12 | PXD019652 | Pride
Histone post-translational modifications Drug safety Toxicoepigenetics Pharmacoepigenetics Screening Proteomics Lc-ms/ms 
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