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ProteomicsQuantitative Pattern of hPTMs by Mass Spectrometry-based Proteomics with Implications for Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, with trend to early relapse and metastasis as well as poor survival. Limited therapies and lack of effective therapeutic targets are one of the main challenges in clinical management of TNBC. Histone post-translationa...
ORGANISM(S): Homo Sapiens 
2024-02-01 | PXD049101 |
UnknownDevelopment of Complementary Photo-arginine/lysine to Promote Discovery of Arg/Lys hPTMs Interactomes.
Not available
S-EPMC11005723 | biostudies-literature
ProteomicsDeciphering the interplay of aflatoxin B1 and Epstein-Barr virus on the histone landscape in Burkitt Lymphoma cells
Aflatoxin B1 (AFB1), a potent dietary carcinogen, and Epstein-Barr virus (EBV), an oncogenic virus, are both implicated in cancer development, particularly in endemic regions. However, the combined effects of AFB1 exposure and EBV infection on the epigenetic landscape remain poorly understood. This ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD060719 | Pride
Human Epstein-barr virus Aflatoxin b1 Hptms Burkitt lymphoma cells Lc-ms/ms 
ProteomicsMulti-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
DNA damage response (DDR) is instrumental for maintaining genome stability and its deregulation predisposes to carcinogenesis, while revealing attractive targets for innovative therapies. Chromatin governs the DNA repair process via the interplay among different layers consisting of DNA, histones po...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD027421 | Pride
Proteomics Hptms Ipoc Chip-sicap Dna damage foci Chromatin Dsb Ddr 
TranscriptomicsDiversity and evolution of chromatin regulatory states across eukaryotes
Histone post-translational modifications (hPTMs) are key regulators of chromatin states, influencing gene expression, epigenetic memory, and transposable element repression across eukaryotic genomes. While many hPTMs are evolutionarily conserved, the extent to which the chromatin states they define ...
ORGANISM(S): Saccharomyces cerevisiae Tetrahymena thermophila Dictyostelium discoideum Spizellomyces punctatus Arabidopsis thaliana Acanthamoeba castellanii Creolimax fragrantissima Physcomitrium patens Nematostella vectensis Bigelowiella natans Naegleria gruberi Guillardia theta 
2026-05-10 | GSE329952 | GEO
GenomicsDiversity and evolution of chromatin regulatory states across eukaryotes [ChIP-Seq]
Histone post-translational modifications (hPTMs) are key regulators of chromatin states, influencing gene expression, epigenetic memory, and transposable element repression across eukaryotic genomes. While many hPTMs are evolutionarily conserved, the extent to which the chromatin states they define ...
ORGANISM(S): Physcomitrium patens Arabidopsis thaliana Acanthamoeba castellanii Tetrahymena thermophila Creolimax fragrantissima Saccharomyces cerevisiae Dictyostelium discoideum Guillardia theta Naegleria gruberi Nematostella vectensis Spizellomyces punctatus Bigelowiella natans 
2026-05-10 | GSE329959 | GEO
ProteomicsComprehensive Histone Epigenetics (CHEpi): A mass spectrometry based screening assay to measure epigenetic toxicity
Epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large scale analysis of histone posttranslational modifications (hPTM...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-10-12 | PXD019652 | Pride
Histone post-translational modifications Drug safety Toxicoepigenetics Pharmacoepigenetics Screening Proteomics Lc-ms/ms 
GenomicsCell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse Striatum
Histone post-translational modifications (hPTMs) regulate gene expression via changes in chromatin accessibility and transcription factor recruitment. At a given locus, the coordinated enrichment of several distinct hPTMs regulate gene expression in response to external stimuli. However, neuronal hP...
ORGANISM(S): Mus musculus 
2022-11-17 | GSE193673 | GEO
ProteomicsDiversity and evolution of chromatin regulatory states across eukaryotes
Histone post-translational modifications (hPTMs) are key regulators of chromatin states, influencing gene expression, epigenetic memory, and transposable element repression across eukaryotic genomes. While many hPTMs are evolutionarily conserved, the extent to which the chromatin states they define ...
ORGANISM(S): Saccharomyces Cerevisiae 
PXD070263 | panorama
ProteomicsUntargeted histone profiling of human embryonic stem cell conversion over time reveals fundamental epigenetic changes between pluripotent and naive states
Recently, various groups managed to isolate naïve human embryonic stem cell (hESC) state in vitro has come into acceptance. However, a thorough epigenetic characterization of this human ground state, defined as a state without any epigenetic restrictions, and how that compares to mouse is currently ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD013067 | Pride
Human embryonic stem cells  pluripotency  naïve  epigenetics  histone modification  mass spectrometry 
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