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TranscriptomicsMapping of meiotic double-strand break (DSB) sites and DSB factor association near repetitive DNA elements in S. cerevisiae
DNA double strand breaks (DSBs) in repetitive sequences are a potent source of genomic instability, due to the possibility of non-allelic homologous recombination (NAHR). Repetitive sequences are especially at risk during meiosis, when numerous programmed DSBs are introduced into the genome to initi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-14 | E-GEOD-30073 | biostudies-arrayexpress
TranscriptomicsChIP-chip of DSB factors in wild type and pch2 strains
ChIP-chip was used to compare DSB factor localization in wild type and pch2 strains 10 samples, 2-3 replicates each. Averaged data is available as a supplementary file on the Series record (below).
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-14 | E-GEOD-30072 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher or...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74855 | biostudies-arrayexpress
TranscriptomicsDSB formation in replication compromised cells
DSBs were mapped genome-wide by ssDNA enrichment in cdc6-mn replication comprimsied strains. We mapped DSB sites by detecting DSB-associated ssDNA enrichment on microarrays. To test the role of DNA replication in DSB formation, we mapped ssDNA in a cdc6-mn replication depleted strain. ssDNA was isol...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-18 | E-GEOD-35666 | biostudies-arrayexpress
GenomicsBES DSB gene expression changes
Effect of a DSB at the active expression site
PRJEB44245 | ENA
ProteomicsID3 Deficiency Alters Chromatin Accessibility at DSB Sites and Enhances Vulnerability to HDAC Inhibition
The inhibitor of DNA-binding 3 (ID3) plays a crucial role in DNA double-strand break (DSB) repair. We previously reported that ID3 loss reduced chromatin accessibility at DNA repair gene promoters, yet its exact role in DNA repair via chromatin regulation remained elusive. Using the AID-DIvA cell sy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD069605 | Pride
Id3 Chromatin accessibility Hdac Dsb Inhibition 
UnknownHELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.
Not available
S-EPMC8755542 | biostudies-literature
TranscriptomicsaCGH analyses of DSB-induced LOH in Blm-deficient mESCs
Genome modification in mouse embryonic stem cells (mESCs) has provided the versatile platform to analyzing gene functions in mammalian cells. Bloom helicase-deficient mESCs showed elevated rate of loss of heterozygosity (LOH) through mitotic recombination. By utilizing this characteristic of Blm de...
ORGANISM(S): Mus musculus 
2012-11-30 | E-MTAB-1116 | biostudies-arrayexpress
GenomicsSpo11-oligo mapping in bas1 and ino4 mutants
Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB for...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-21 | E-GEOD-67910 | biostudies-arrayexpress
GenomicsPRDM9 methyltransferase is essential for meiotic DSB formation
PRDM9 methyltransferase is essential for meiotic DSB formation
PRJNA429240 | ENA
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