211218 Results

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MetabolomicsUntargeted lipid profiling following mTOR inhibition

The mechanistic target of rapamycin (mTOR) is pivotal in programming cellular lipid homeostasis for the structural and functional integrity of cells. Dysregulation of mTOR and consequent altered lipid metabolism are common features in various diseases, including cancers, making mTOR signaling a p...

2025-09-20 | MTBLS12837 | MetaboLights
MetabolomicsInhibition of anaerobic digestion by various ammonia sources resulted in subtle differences in metabolite dynamics

The impact of ammonia on anaerobic digestion performance and microbial dynamics has been extensively studied, but the concurrent effect of anions brought by ammonium salt should not be neglected. This paper studied this effect using metabolomics and a time-course statistical framework. Metabolomi...

2024-03-01 | MTBLS7859 | MetaboLights
MetabolomicsXenopus tropicalis glycolysis and PPP inhibition
Not available
ORGANISM(S): Xenopus tropicalis 
ST002270 | MetabolomicsWorkbench
MetabolomicsInhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle
Not available
ORGANISM(S): Mus musculus 
ST000513 | MetabolomicsWorkbench
MetabolomicsSystemic metabolite changes due to PHD inhibition
Not available
ORGANISM(S): Mus musculus 
ST001866 | MetabolomicsWorkbench
MetabolomicsWNK463 Inhibition on Right Ventricular metabolomics
Not available
ORGANISM(S): Rattus norvegicus 
ST001869 | MetabolomicsWorkbench
MetabolomicsDivergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...
2021-07-20 | MTBLS2372 | MetaboLights
MetabolomicsEffects of ODC inhibition on T cell metabolism
Not available
ORGANISM(S): Mus musculus 
ST000955 | MetabolomicsWorkbench
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsBurkholderia cenocepacia-mediated inhibition of Staphylococcus aureus growth and biofilm formation

Staphylococcus aureus asymptomatically colonizes the nasal cavity and pharynx of up to 60% of the human population and, as an opportunistic pathogen, can breach its normal habitat, resulting in life-threatening infections. S. aureus infections are of additional concern for populations with impair...

2024-11-26 | MTBLS11049 | MetaboLights
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