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GenomicsAF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress
ProteomicsA Chemical Acetylation based Mass Spectrometry Platform for Histone Profiling
Here we present a strategy for the identification and quantitation of histone methylation that utilizes nondeuterated acetic anhydride to fully acetylate all free lysine residues prior to digestion with trypsin and analysis by LC-MS/MS.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086146 | MassIVE
ProteomicsRole of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium
The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that exists in both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity. While...
ORGANISM(S): Dictyostelium Discoideum Ax2 
2021-06-15 | PXD024225 | panorama
GenomicsDissecting the Role of H3K27 Acetylation and Methylation in PRC2 Mediated Control of Cellular Identity
Dissecting the Role of H3K27 Acetylation and Methylation in PRC2 Mediated Control of Cellular Identity
PRJNA479477 | ENA
TranscriptomicsGenome-wide profiling of H3K9/K14 Acetylation and H3K27 trimethylation at promoters in the human lung embryonic fibroblast cell line MRC5
Genome-wide profiling of H3K9/K14 Acetylation and H3K27 trimethylation at promoters in the human lung embryonic fibroblast cell line MRC5
ORGANISM(S): Homo sapiens 
2013-11-11 | E-MTAB-2004 | biostudies-arrayexpress
GenomicsHistone H3K27 methylation states are sequentially catalyzed in cycling cells
Histone H3K27 methylation states are sequentially catalyzed in cycling cells
PRJNA1452821 | ENA
UnknownConcurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior.
Not available
S-EPMC3948868 | biostudies-literature
ProteomicsMetabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
PFA ependymomas are a lethal glial malignancy of the hindbrain found in babies and toddlers. Lacking any highly recurrent somatic mutations, PFAs have been proposed as a largely epigenetically driven tumor type. An almost complete lack of model systems has inhibited discovery of novel PFA therapies....
ORGANISM(S): Homo sapiens (Human) 
2020-08-13 | PXD018191 | Pride
Proteomics H3k27 methylation and acetylation Pfa ependymomas 
UnknownDissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.
Not available
S-EPMC6459869 | biostudies-literature
GenomicsNOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression
NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression
PRJNA983788 | ENA
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