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TranscriptomicsLung expression data from highly pathogenic H5N1 virus infected and uninfected mice
Susceptible and Resistant mouse strain, e.g. DBA/2J and C57BL/6J respectively, were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 72 hours. Differences in expression were analyzed and use to identify candidate genes and pathways that contributed to the differe...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64750 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of HUVEC infected with Influenza virus
To delineate specific patterns of signaling networks activated by H5N1 we used a comparative systems biology approach analyzing gene expression in endothelial cells infected with three different human and avian influenza strains of high and low pathogenicity. HUVECs were infected with either PR8, F...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-13637 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of lungs from six different mouse strains after infection with highly pathogenic H5N1 influenza A virus [set 2]
Susceptible (DBA/2J, 129/SvImJ, A/J) and Resistant (SM/J, C57BL/6J, Balb/cJ) mouse strain were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 72 hours or not infected (control animals). Differences in expression were analyzed and used to identify candidate gen...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64799 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of lungs from six different mouse strains after infection with highly pathogenic H5N1 influenza A virus [set 1]
Susceptible (DBA/2J, 129/SvImJ, A/J) and Resistant (SM/J, C57BL/6J, Balb/cJ) mouse strain were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 24 and 168 hours. Uninfected control animals were included. Differences in expression were analyzed and used to identi...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64798 | biostudies-arrayexpress
TranscriptomicsExpression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [24 hours post infection]
Recently, a novel protein in the influenza virus segment 3 has been identified, namely PA-X. This small protein has been reported to play a role in modulating host response of the 1918 H1N1 pandemic virus-infected mice. However, poteinal role of this protein in the pathogenicity and regulating host ...
ORGANISM(S): Gallus gallus 
2015-03-04 | E-GEOD-53931 | biostudies-arrayexpress
TranscriptomicsAn ultrasensitive mechanism regulates influenza virus-induced inflammation
Whole-genome, time-course data was developed from the lungs of influenza infected mice to better characterize the dynamics of the host immune response during infection. Lung for microarray studies were obtained from female, five-week old C57BL/6Js infected with influenza viruses. Forty-two animals ...
ORGANISM(S): Mus musculus 
2015-06-12 | E-GEOD-63786 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of chickens (Gallus gallus) infected with recombinant influenza viruses
H5N1 subtype highly pathogenic avian influenza virus has been spreading to Asia, Eurasia and African coutries. An original or six of recombinant H5N1 subtype influenza viruses with varying survivability were infected to chickens for elucidating genes correlated with pathogenicity. Two chickens were ...
ORGANISM(S): Gallus gallus 
2012-03-30 | E-GEOD-32378 | biostudies-arrayexpress
TranscriptomicsExpression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [12 hours post infection]
Recently, a novel protein in the influenza virus segment 3 has been identified, namely PA-X. This small protein has been reported to play a role in modulating host response of the 1918 H1N1 pandemic virus-infected mice. However, poteinal role of this protein in the pathogenicity and regulating host ...
ORGANISM(S): Gallus gallus 
2015-03-04 | E-GEOD-53930 | biostudies-arrayexpress
GenomicsInfluenza A virus strain:H5N1
H5N1 Influenza A virus Raw sequence reads
PRJNA381590 | ENA
TranscriptomicsGene expression signature-based screening identifies new broadly effective influenza antivirals
Classical antiviral therapy inhibit viral proteins and are subject to resistance. To counteract this emergence, alternative strategy has been developed that target cellular factors. We hypothesized that such approach could also be useful to identify broad antivirals. Influenza A virus was used as a ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-22319 | biostudies-arrayexpress
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