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TranscriptomicsTop1 and Top2-mediated replication fork integrity
DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-8305 | biostudies-arrayexpress
TranscriptomicsGene expression in natural subyearling fall Chinook salmon in the Snake and Clearwater Rivers
We used gene expression accompanied by physical characteristics and gill Na+/K+-ATPase activity to analyze physiological differences associated with two life history variations of juvenile fall Chinook Salmon in the Snake River basin. Subyearlings originating in the Snake River typically migrate sea...
ORGANISM(S): Oncorhynchus tshawytscha 
2014-06-20 | E-GEOD-58670 | biostudies-arrayexpress
UnknownOvercoming sequence misalignments with weighted structural superposition.
Not available
S-EPMC3464347 | biostudies-literature
GenomicsLigand-dependent dynamics of retinoic acid receptor binding during early neurogenesis
Among its many roles in development, retinoic acid determines the anterior-posterior identity of differentiating motor neurons by activating Retinoic Acid Receptor (RAR)-mediated transcription. RAR is thought to bind the genome constitutively, and only induce transcription in the presence of the ret...
ORGANISM(S): Mus musculus 
2010-12-10 | E-GEOD-19409 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell differentiation following treatment with DKK1
Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.
ORGANISM(S): Mus musculus 
2006-12-31 | E-MEXP-759 | biostudies-arrayexpress
TranscriptomicsDSIF and RNA polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of RNA polymerase II, to prevent cryptic initiation within genes. Meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-11-28 | E-GEOD-22636 | biostudies-arrayexpress
GenomicsHoxc9 ChIP-seq in differentiating motor neurons
The expression of v5-tagged Hoxc9 is induced and ChIP-seq is used to profile genome-wide occupancy in differentiating motor neurons The differentiation of ventral motor neurons is induced by treating embryonic stem cell cultures with retinoic acid and hedgehog signaling. Here, ChIP-seq is used to pr...
ORGANISM(S): Mus musculus 
2010-09-08 | E-GEOD-21812 | biostudies-arrayexpress
UnknownConformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Not available
S-EPMC2574997 | biostudies-literature
UnknownThe biogeography of the Amazonian tree flora.
Not available
S-EPMC11446918 | biostudies-literature
GenomicsChromatin landscape of progenitor motor neurons [ChIP-seq]
Progenitor motor neurons can be generated with high-efficiency by differentiating ES cells in vitro in the presence of retinoic acid and hedgehog signalling. Here, we characterize the chromatin landscape associated with progenitor motor neurons (pMNs) in order to assess how histone modification doma...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-39434 | biostudies-arrayexpress
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