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ProteomicsA tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling
Pseudomonas aeruginosa is a difficult-to-treat Gram-negative bacterial pathogen causing life-threatening infections. Adaptive resistance (AR) to cationic peptide antibiotics such as polymyxin B impairs the therapeutic success. This self-protection is mediated by two component systems (TCS) consistin...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Escherichia coli Bacillus subtilis 
2021-02-16 | PXD022426 | Pride
Response regulator P. aeruginosa Adaptive resistance Antimicrobial peptide Phosphorylation Activity-based protein profiling Parallel reaction monitoring Isotopically labeled tags B. subtilis 
ProteomicsNonsense-mediated decay in Plasmodium falciparum
We have HA-tagged two nonsense-mediated decay proteins, UPF1 and UPF2, in the malaria parasite Plasmodium falciparum. We then performed co-immunoprecipitation experiments to determine the protein-protein interactions of these nonsense-mediated decay components.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-04-16 | PXD023910 | Pride
Malaria Co-immunoprecipitation Mrna Nonsense-mediated decay Plasmodium falciparum 
ProteomicsRelease of the plant peptide hormone PEP1 from its precursor PROPEP1 in response to physical damage is due to Ca2+-dependent activation of METACASPASE4.
Physical damage to cells leads to the release of immunomodulatory peptides in order to elicit wound defense responses in the surrounding tissue. In Arabidopsis thaliana, the intracellular PROPEP1 protein precursor is processed into the mature 2.5 kDa PEP1 before release. However, the maturation mech...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-18 | PXD010816 | Pride
Arabidopsis Protease Metacaspase4 Proteolysis Propep Physical damage 
ProteomicsEffects of PGRMC1 phosphorylation status on MIA PaCa-2 cells
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biolo...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD014716 | Pride
Proteomics Swath Phosphorylation Pancreatic cancer 
TranscriptomicsEarly and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.
This study revealed important similarities but also critical differences between the H5N1 and 1918-reassortant viruses, highlighting aspects of the host–pathogen interface caused by highly virulent influenza viruses. Animals assigned to 4 experimental groups (n = 8) matched for age, weight, and sex,...
ORGANISM(S): Macaca fascicularis 
2011-11-01 | E-GEOD-33351 | biostudies-arrayexpress
ProteomicsCompare total proteomics profile of PaCa-2 cells using 1D and 2D IDA LC and SWATH analysis
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biolo...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD014789 | Pride
Cancer Proteomics Swath 
TranscriptomicsTranscription profiling of mouse ck-OBF-1 transgene
The Lck-OBF-1 construct used to generate transgenic mice contains an N-terminally HA epitope-tagged human OBF-1 cDNA under the control of the murine proximal lck promoter (-3100 to +23 relative to the transcription start site) that was purified by electroelution. Transgenic mouse lines were obtained...
ORGANISM(S): Mus musculus 
2006-10-25 | E-MEXP-85 | biostudies-arrayexpress
UnknownEye-tracking-based visual field analysis (EFA): a reliable and precise perimetric methodology for the assessment of visual field defects.
Not available
S-EPMC7978082 | biostudies-literature
UnknownInteractions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes.
Not available
S-EPMC7920835 | biostudies-literature
GenomicsCIDR: Genome Wide Association Study in Familial Parkinson Disease (PD)

This proposal brings together the two largest NIH funded genetic studies focused on the identification of novel genes that influence the risk of PD. These two studies, PROGENI (PI: Tatiana Foroud; R01NS037167) and GenePD (PI: Richard Myers; R01NS036711) have been evaluating and recruiti...

phs000126.v1.p1 | EGA
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