Sort   by:  
 Page size 
ProteomicsMudPIT analyses of whole cell extracts from Y1 murine adrenocortical carcinoma cell line stimulated with serum or FGF2
Fibroblast growth factor 2 (FGF2) is well known as a promoter of cell proliferation, however, in some cellular contexts, it can induce cell cycle arrest or cell death. In Y1 murine adrenocortical carcinoma cell line, FGF2 induces G0/G1 transition but delays S-phase progression and permanently block ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-23 | MSV000081638 | MassIVE
TranscriptomicsImpact of NRSF variant over-expression in SK-N-AS human neuroblastoma cells
Neuron-restrictive silencer factor (NRSF) and its isoforms are differentially regulated in rodent models of self-sustaining status epilepticus (SSSE). NRSF isoforms regulate genes associated with SSSE, including the proconvulsant tachykinins, brain-derived neurotrophic factor and multiple ion cha...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22467 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines MCF7, COLO-205 and SK-MEL-5 following treatment with PEP008
We previously identified the induction of growth arrest with phenotypic characteristics of senescence in melanoma cell lines sensitive to diterpene esters, indicating a therapeutic potential. Here we compared the cytostatic effects of two diterpene esters namely TPA (12-O-tetradecanoylphorbol-13-ac...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8742 | biostudies-arrayexpress
UnknownChannelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity.
Not available
S-EPMC8844225 | biostudies-literature
UnknownDifferent arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation.
Not available
S-EPMC7681919 | biostudies-literature
UnknownHydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels.
Not available
S-EPMC7736289 | biostudies-literature
TranscriptomicsS. cerevisiae mutant with a constitutively activated Ras/cAMP pathway
Comparison of the transcriptomes of Saccharomyces cerevisiae wild type FY23 and a PDE2 deletion mutant DJ28. Keywords = PDE2 Keywords = Ras/cAMP pathway
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-600 | biostudies-arrayexpress
GenomicsChIP-Seq for cofactors in cancer
Critical drivers of cancer progression are likely controlled through the actions of transcription factors and cofactors that bind to the genome and form enhancers that stimulate gene expression. We present ChIP-seq analysis of key transcriptional regulators, cofactors and histone modifications that...
ORGANISM(S): Homo sapiens 
2013-04-13 | E-GEOD-45984 | biostudies-arrayexpress
ProteomicsChemical Genetic Identification of Cyclin-G-associated kinase (GAK) Substrates Reveals its Role in Regulating Na+/K+-ATPase and Sipa1L1 in Neurons
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a Parkinson’s disease risk. However, its role in neuronal function and many downstream effectors remain unclear. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-07 | PXD011319 | Pride
Cyclin-g-associated kinase Sodium potassium pump Atp1a3 Gak 
TranscriptomicsLentiviral shRNA library screen to identify growth-related genes in malignant melanoma
Little is known about genes that promote melanoma cell growth and proliferation. siRNAs may be used to address the role of individual genesin these processes. RNAi library screens were used in the past to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration an...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-46675 | biostudies-arrayexpress
Sort   by:  
 Page size