Sort   by:  
 Page size 
ProteomicsChemical Genetic Identification of Cyclin-G-associated kinase (GAK) Substrates Reveals its Role in Regulating Na+/K+-ATPase and Sipa1L1 in Neurons
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a Parkinson’s disease risk. However, its role in neuronal function and many downstream effectors remain unclear. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-07 | PXD011319 | Pride
Cyclin-g-associated kinase Sodium potassium pump Atp1a3 Gak 
ProteomicsGAK and PRKCD are positive regulators of Parkin-independent mitophagy
Mitophagy plays a key cellular role for the programmed or damage induced removal of mitochondria, however, precisely how this process is orchestrated in response to different stimuli still requires investigation. In this work we have screened for regulators of PARKIN-independent mitophagy using an s...
ORGANISM(S): Homo sapiens (Human) 
2021-09-29 | PXD022773 | Pride
Gak Dfp Prkcd Mitophagy Protein kinase c delta Cyclin g associated kinase 
GenomicsLoss of Gak leads to lysosome dysfunction and immune modulation in podocytes
Loss of Gak leads to lysosome dysfunction and immune modulation in podocytes
PRJNA1288537 | ENA
TranscriptomicsLoss of Gak leads to lysosome dysfunction and immune modulation in podocytes
Lysosome impairment causes cellular and organ dysfunction, highlighting its crucial role in homeostasis. In this study, we uncovered the indispensable role of cyclin G-associated kinase (GAK) in maintaining podocyte lysosome integrity. We previously showed that podocyte-specific loss of Gak (Gak-KO)...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE302106 | GEO
GenomicsGlomerular microRNA data of the kidney podocyte-specific cyclin-G associated kinase (Gak) deficient mice
Glomerular microRNA data of the kidney podocyte-specific cyclin-G associated kinase (Gak) deficient mice
PRJNA665044 | ENA
TranscriptomicsLncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis
Long noncoding RNAs (lncRNAs) have been found to regulate the expression of mRNAs with which they share partial complementarity. We sought to identify the mechanism through which the lncRNA OIP5-AS1, which is abundant in the cytoplasm, suppressed cell proliferation. Silencing of OIP5-AS1 in human ce...
ORGANISM(S): Homo sapiens 
2017-09-25 | GSE93551 | GEO
UnknownThe cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation.
Not available
S-EPMC9327206 | biostudies-literature
TranscriptomicsGlomerular microRNA data of the kidney podocyte-specific cyclin-G associated kinase (Gak) deficient mice
Evidence for reduced expression of cyclin-G associated kinase (GAK) in glomeruli of chronic kidney disease patients was observed in the Nephroseq human database and was found to be associated with the decline in kidney function. To examine the role of GAK, a protein that functions to uncoat clathrin...
ORGANISM(S): Mus musculus 
2020-12-08 | GSE158384 | GEO
UnknownDynamic early recruitment of GAK-Hsc70 regulates coated pit maturation.
Not available
S-EPMC12146748 | biostudies-literature
UnknownTargeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics.
Not available
S-EPMC8416139 | biostudies-literature
Sort   by:  
 Page size