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TranscriptomicsTranscriptome-wide identification of LARP4B binding sites in HEK293 cells
mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting “mRNP code” determines the fate of any given mRNA and thus ...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-69169 | biostudies-arrayexpress
TranscriptomicsDeregulated Myc expression induces addiction to AMPK-related kinase 5
U2OS cells were infected with shRNA vector targeting Ark5 or control vector, selected on puromycin for 48hrs, seeded on 5cm dishes at 20% confluency and harvested in triplicate 48hrs later
ORGANISM(S): Homo sapiens 
2012-03-01 | E-MEXP-3543 | biostudies-arrayexpress
TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
TranscriptomicsIsolation and sequencing of AGO-bound RNAs reveals characteristics of stem-loop processing in vivo
MicroRNA precursors (pre-miRNAs) are short hairpin RNAs that are rapidly processed into mature microRNAs (miRNAs) in the cytoplasm. Due to their low abundance in cells, sequencing-based studies of pre-miRNAs have been limited. We successfully enriched for and deep sequenced pre-miRNAs in human cells...
ORGANISM(S): Homo sapiens 
2016-07-30 | E-GEOD-71710 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced modulation of gene expression in human adipocytes - A microarray study
Obesity is characterised by expansion of white adipose tissue, accompanied by an inflamatory response. It has been proposed that the inflammatory state observed may be linked to relative hypoxia in clusters of adipocytes distant from vasculature. Adipose tissue hypoxia has been observed in both an...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-34007 | biostudies-arrayexpress
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
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