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Objective: Recent genome-wide association studies (GWAS) identified a variant rs7575840 in the apolipoprotein B (APOB) gene region to be associated with LDL-C. However, the underlying functional mechanism of this variant that resides 6.5 kb upstream of APOB has remained unknown. Our objective was to...
ORGANISM(S): Homo sapiens 
SCLC - Whole genome sequencing data Publication Peifer et al., 2012, Nature Genetics
SCLC - RNA sequencing data Publication Peifer et al., 2012, Nature Genetics
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype. We conducted integrated analysis of genome sequencing, transcriptome, and copy number analysis and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Evidence for inactivation of TP53 and...
SNP 6.0 arrays of small cell lung cancer
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