Sort   by:  
 Page size 
UnknownSerpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach.

Background

Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is SERPINE1 whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of SERPINE1 in DN ...
S-EPMC8701119 | biostudies-literature
UnknownMultiple Sclerosis: Shall We Target CD33?
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). Myeloid lineage cells (microglia and macrophages) may participate in the pathogenic mechanisms leading to MS. CD33 is a transmembrane receptor, mainly expressed by myeloid lineage cells. CD33 rs3865444 is a promoter va...
S-EPMC7696272 | biostudies-literature
UnknownInvestigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.

Background

Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.

Objective

We used results from genome-wide association studies (GWASs) to study the genetic...
S-EPMC10334300 | biostudies-literature
UnknownAQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury.
Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling th...
S-EPMC4238262 | biostudies-literature
UnknownMusculoskeletal Pain Due to Wheelchair Use: A Systematic Review and Meta-Analysis.

Introduction

Wheelchair users are at a high risk of experiencing non-neuropathic pain of musculoskeletal origin as a result of being wheelchair-bound. The aim of this systematic review was to establish the prevalence of musculoskeletal pain in wheelchair users that is attributable to wheelch...
S-EPMC8586284 | biostudies-literature
UnknownGenome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with ...
S-EPMC11176086 | biostudies-literature
UnknownThe Role of TOR1A Polymorphisms in Dystonia: A Systematic Review and Meta-Analysis.

Importance

A number of genetic loci were found to be associated with dystonia. Quite a few studies have been contacted to examine possible contribution of TOR1A variants to the risk of dystonia, but their results remain conflicting. The aim of the present study was to systematically evaluate...
S-EPMC5231385 | biostudies-literature
UnknownSORL1 mutation in a Greek family with Parkinson's disease and dementia.
Whole exome sequencing and linkage analysis were performed in a three generational pedigree of Greek origin with a broad phenotypic spectrum spanning from Parkinson's disease and Parkinson's disease dementia to dementia of mixed type (Alzheimer disease and vascular dementia). We identified a novel h...
S-EPMC8528452 | biostudies-literature
UnknownWorldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.

Background

Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 2...
S-EPMC7615769 | biostudies-literature
UnknownDiminishing benefits of urban living for children and adolescents' growth and development.
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1-6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of child...
S-EPMC10060164 | biostudies-literature
Sort   by:  
 Page size