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TranscriptomicsExpression data from monocytic cell lines (THP)
The experiment aims to identify transcriptional effects of Infliximab (an anti-TNF antibody) and CDP870 on human cell lines Results were generated using 3 timepoints: 0h, 6h, and 24h with each stimuli. 3 biological replicates in each of the 5 groups: oh control; 6h IFX; 24h IFX; 6h CDP870; 24h CDP87...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33585 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data from human cell lines (Panc1 cells)
The experiment aims to identify miRNAs that are regulated in response to TRAIL R1 si-RNA and TRAIL R2 si-RNA. The overall aim of the study was to identify mechanisms by which TRAIL death receptors may contribute to malignancy via inhibition of let-7 maturation. Comparison of TRAIL R1 si-RNA vs. cont...
ORGANISM(S): Homo sapiens 
2013-11-20 | E-GEOD-37734 | biostudies-arrayexpress
TranscriptomicsCD4+CD+8 double positive T-cell mRNA expression profiles from patients with granulomatotis with polyangiitis (GPA) compared to healthy controls
Expansion of circulating CD4+CD8+ double positive (DP) T-cells in a disease context is poorly understood. The study aims to identify mechanisms which may drive expansion of CD4+CD8+ double positive t-cells in GPA. PBMCs from 3 GPA patients and 3 healthy controls were used to generate mRNA profiles f...
ORGANISM(S): Homo sapiens 
2014-10-03 | E-GEOD-56481 | biostudies-arrayexpress
TranscriptomicsGenome wide expression data from discordant twins (ulcerative colitis, primary mucosal tissue)
Background and aims. The etiopathology of inflammatory bowel diseases is still poorly understood. To date, only few little data are available on the microbiota composition in ulcerative colitis (UC), representing a major subform of inflammatory bowel diseases. Currently, one of the main challenges i...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-22619 | biostudies-arrayexpress
TranscriptomicsExpression data from gingival tissue
The experiment aims to identify transcriptional effects differences between periimplantitis, Parodontitis and healthy gingival tissue 8 controls, 7 periimplantitis patients, 7 Parodontitis patients
ORGANISM(S): Homo sapiens 
2012-10-29 | E-GEOD-33774 | biostudies-arrayexpress
TranscriptomicsMus musculus intestine
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-21746 | biostudies-arrayexpress
TranscriptomicsMicroarray expression data from the Mus musculus intestine
Genome wide expression profiling to determine the overlap of Affymetrix-signals with SOLID sequencing RNA was extracted using the Qiagen RNeasy kit following the manufacturers guidelines, arrays were prepared and hybridized following the Affymetrix protocol. Mus musculus samples from small intestine...
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-19767 | biostudies-arrayexpress
TranscriptomicsExpression data from Adam10 knock out mice and wild type
Adam10, a cell surface protease, cleaving many proteins including TNF-alpha and E-cadherin. Here we investigate the genome wide effects of Adam10 knock out on the transcriptome. Commercial microarrays (Affymetrix Mouse Gene ST 1.0) were used to generate genome wide mRNA profiles. Mouse tissue sample...
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-25480 | biostudies-arrayexpress
TranscriptomicsArchitectural complexity of the polyadenylated intestinal transcriptome revealed by hybrid RNA sequencing
We report the complexity of the polyadenylated transcriptome of the mouse intestinal tract assessed by a hybrid RNA-sequencing. We show that 90.72% of the polyA-derived unique reads map to known genes, but 9.28% of reads matched to nonannotated genomic regions. Screening and verification of non-ann...
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-21699 | biostudies-arrayexpress
TranscriptomicsTwo-step RNA sequencing identifies a tissue-specific landscape of sense/antisense transcription
We report the complexity of the polyadenylated transcriptome of the mouse intestinal tract assessed by two step RNA sequencing. Screening and verification of non-annotated transcriptional units by different RNA-Seq protocols.
ORGANISM(S): Mus musculus 
2011-03-29 | E-GEOD-28207 | biostudies-arrayexpress
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