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ProteomicsReproducible Workflow for Multiplexed Deep-Scale Proteome and Phosphoproteome Analysis of Tumor Tissues by Liquid Chromatography-Mass Spectrometry

Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, Clauser KR, Clauss TR, Shah P, Gillette MA, et al., Nat Protoc. 2018 Jul 9. doi: 10.1038/s41596-018-0006-9

Here we present an optimized workflow for gl...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-30 | MSV000084265 | MassIVE
TranscriptomicsExpanding the Pathways of Manganese Homeostasis: Role of a Small Manganese Chaperone Protein, MntS
Escherichia coli possesses >65 small proteins of <50 amino acids, many of which are uncharacterized. We have identified a new small protein, MntS, involved in manganese homeostasis. Manganese is a critical micronutrient, serving as an enzyme cofactor and protecting against oxidative stress. Yet mang...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-12-08 | E-GEOD-25318 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Rattus norvegicus brain hippocampal CA1 regions after kainic acid induced status epilepticus and untreated controls.
In this study we used microarray analysis to reveal the gene expression profile of the hippocampal CA1 subregion, which was laser-capture microdissected one week after kainic acid (KA)-induced status epilepticus (SE) in postnatal day 21 (P21) rats. These rats are developmentally roughly comparable t...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-TABM-881 | biostudies-arrayexpress
GenomicsAmplicon Sequencing of gRNAs from Brunello CRISPR mutagenized A549 and U87-MG cells after live/dead selection with EV-D68 IL
With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM)). In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outb...
ORGANISM(S): Homo sapiens 
2025-02-25 | E-MTAB-14765 | biostudies-arrayexpress
ProteomicsA novel quantitative mass spectrometry platform for determining site-specific protein O-GlcNAcylation dynamics
Over the past decades, protein O-GlcNAcylation has been found to play a fundamental role in cell cycle control, metabolism, transcriptional regulation, and cellular signaling. Nevertheless, quantitative approaches to determine in vivo GlcNAc dynamics at a large-scale are still not readily available....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080705 | MassIVE
UnknownClarin-2 is essential for hearing by maintaining stereocilia integrity and function
Not available
S-SCDT-EMM-2019-10288 | biostudies-other
TranscriptomicsLubiprostone effects on small intestinal gene expression in wild type and Cftr-null mice
Background: Cystic fibrosis (CF) is caused by mutations in the CFTR gene that impair function of this cAMP-regulated Cl- channel. In the small intestine, loss of CFTR function creates a dehydrated, acidic luminal environment which is believed to cause an accumulation of mucus, a phenotype characteri...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-18327 | biostudies-arrayexpress
GenomicsMelanoma Genome Sequencing Project

Melanoma is the most prevalent cause of skin cancer morbidity and mortality. In order to characterize the full range of somatic mutations that may drive the growth of melanoma, we are sequencing tumor and normal DNA from a set of roughly 150 melanomas. For the majority of samples (approximately 9...

phs000452.v1.p1 | EGA
TranscriptomicsTranscription profiling of V. vinifera Cabernet sauvignon and V. aestivalis Norton innoculated with Erysiphe necator conidiospores
we analyzed pathogen-induced changes in the transcriptome of Vitis vinifera ‘Cabernet sauvignon’ and Vitis aestivalis ‘Norton’ by conducting a large-scale study to measure transcript abundance at 0, 4, 8, 12, 24, and 48 hours post-treatment in conidiospore- and mock-inoculated leaves using A...
ORGANISM(S): Vitis aestivalis 
2008-06-14 | E-GEOD-6404 | biostudies-arrayexpress
TranscriptomicsAmniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome
Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Tu...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-58435 | biostudies-arrayexpress
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